Fig. 3. Deletion profiling using MIP sequencing of pfhrp2 (chromosome 8), pfhrp3 (chromosome 13) and flanking regions applied to 375 field samples.

Samples are grouped by subtelomeric structural profile, with control strains denoted CT, as labelled along the right y axis. LC (low concentration) and HC (high concentration) controls include mixtures of 1% HB3, 10% DD2, 89% 3D7 strains at densities of 250 and 1,000 parasites per µl, respectively. Columns represent each MIP target segment, rows represent individual samples and the colour scale represents log₁₀(UMI) depth-of-coverage at each location. Columns are labelled by the midpoint of each probe’s target region.