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. 2021 May 17;35(10):2936–2947. doi: 10.1038/s41375-021-01275-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A Representative images of zebrafish larvae at 48 hpi. Addition of RAP-536 to GDF-11 pre-treatment of co-cultured MSCs rescued the survival and homing of HSPCs in the CHT region. Surviving HSPCs (magenta) are indicated by white arrowheads, the vasculature is labeled in green. Scale bar 500 µm. B Quantification of HSPCs in the tail region at 48 hpi. One representative experiment is shown, N = 20 embryos in each group, **p < 0.01, ****p < 0.0001. Significance was assessed with Kruskal–Wallis test followed by Dunn’s multiple comparisons post-hoc test.