Fig. 7. The stromal improvement by luspatercept in vivo supports normal but not MDS HSPCs.

Representative images of co-cultures of MDS MSCs before (left) and after luspatercept treatment (right) with HSPCs from healthy donors (A) or the same MDS patient (B) at day 7. C After 1 week of co-culture, a CFU assay was performed for 14 days in methylcellulose medium and the colonies were classified using the StemVision system. Data are shown from one experiment in duplicate as mean ± SD, **p < 0.01 by two-way ANOVA with Tukey’s multiple comparisons test.