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. 2021 Jun 17;35(10):2964–2977. doi: 10.1038/s41375-021-01325-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Prior experiment, cells were expanded for 7 days in the control medium without hiPSC-EVs and were subsequently treated with hiPSC-EVs for 2 h. Next, cell lysates were subjected to the assessment of protein phosphorylation by the Proteome Profiler Human Phospho-Kinase Array Kit. A Relative levels of protein phosphorylation on indicated amino acids are presented as a –fold change compared to the control (cells untreated with hiPSC-EVs). Data are presented as the mean ± SD (N = 2). The red line indicates the level of the control (expressed as 1). When few phosphorylation sites were analyzed within the same protein, a particular amino acid site was indicated. Alternative protein names are included in the brackets. The color coding of the graph bars corresponds to the phosphorylation level ranges as indicated on the graph legend. B PANTHER Pathway Overrepresentation Test. Only proteins with phosphorylation –fold change >1.5 were used in the analysis. The graph presents molecular pathways (PANTHER Pathways) that involve the indicated number of analyzed protein subsets. The color coding of the graph bars, indicated on the graph legend, corresponds to the subjective classification of pathways according to their predominant function in hematopoietic cells. C STRING analysis of the interaction between proteins (presented as spheres) used in the PANTHER analysis was performed in two modes. Left panel: “Molecular action” mode analysis. Line colors between proteins indicate the predicted mode of action, including action types or action effects. Right panel: “Evidence” mode analysis. Line colors between proteins indicate the type of interaction evidence, including known interactions, predicted interactions, or others.