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. 2021 Jun 30;35(10):2813–2826. doi: 10.1038/s41375-021-01318-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — A Intracellular metabolites from FVA analysis showing a significant different intensity between NPM1-mut (n = 8) and NPM1-wt (n = 12, normal karyotype) in MS analysis. Metabolite intensity normalized on DNA concentration is shown in the plot. Significance was obtained by Welch t-test (*p ≤ 0.05). B NPM1/cohesin-mut specific metabolic reaction perturbation network. (red: minimum flux, green: maximum flux, light blue: no information among NPM1/cohesin-mut-specific alterations). Sizes of nodes are proportional to links originating from that node and pointing towards others (outdegree). C Intracellular metabolite intensity of NPM1/cohesin-mut-specific perturbations predicted by FVA (NPM1/cohesin-mut, n = 4; NPM1-mut, n = 8, NPM1-wt, n = 12, normal karyotype). Metabolite intensity normalized on DNA concentration is shown in the plot. Significance was obtained by Welch t-test (*p ≤ 0.05, **p ≤ 0.01).