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. 2021 May 21;35(10):2948–2963. doi: 10.1038/s41375-021-01267-5

Fig. 3. Overexpression of Evl deregulates pathways important to lymphoid cells whereas miR-342 alters myeloid associated signaling.

Fig. 3

a Global gene expression profiling of LSK cells overexpressing Evl or miR-342 after 11 days in culture. 190 and 90 transcripts were significantly deregulated (FoldChange > 2) in Evl or miR-342 overexpressing cells compared to mock transduced cells, respectively. b The top five deregulated pathways upon Evl or miR-342 overexpression are displayed ranked by their −log(p value). c Potential upstream regulators identified in primary LSK cells after overexpression of Evl. Orange circles indicate activation (positive z-score) in murine primary LSK cells upon Evl expression and blue circles represent potential inhibited regulators (negative z-score) based on microarray data analysis using the Ingenuity Pathway Analyzer in Evl expressing (Evl OE) and mock transduced control (ctrl) LSK cells. d FC in log2 of the 12 transcription factors deregulated in Evl OE LSK cells compared to mock ctrl.