Table 7:

Test Characteristics for ultrasound findings to predict neurodevelopmental outcome. Test negative group consists of infants with neither IVH nor WMD. Test positive group consists of infants with ultrasound abnormality listed in the left-most column.

Prediction of neurological disorder†
	Sensitivity	Specificity	+LR	−LR
Isolated IVH	21 (14, 29)	85 (82, 87)	1.4 (0.9, 2.0)	0.93 (0.85, 1.03)
Isolated WMD	16 (10, 24)	98 (96, 99)	8.2 (4.0, 16.7)	0.85 (0.8, 0.9)
IVH + WMD	27 (20, 36)	95 (93, 97)	6.0 (3.8, 9.6)	0.8 (0.7, 0.9)
Prediction of cognitive impairment
	Sensitivity	Specificity	+LR	−LR
Isolated IVH	20 (14, 27)	85 (82, 87)	1.3 (0.9, 1.8)	0.95 (0.87, 1.03)
Isolated WMD	10 (6, 16)	97 (95, 98)	3.3 (1.6, 6.5)	0.9 (0.88, 0.98)
IVH + WMD	21 (15, 29)	95 (93, 97)	4.2 (2.6, 6.6)	0.8 (0.76, 0.90)

Abbreviations: IVH- intraventricular hemorrhage; LR- likelihood ratio; WMD- white matter damage defined as cerebral echolucency or late moderate-to-severe ventriculomegaly

^†Neurological disorder refers to presence of cerebral palsy, autism spectrum disorder, and/or epilepsy