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. Author manuscript; available in PMC: 2022 Oct 1.
Published in final edited form as: J Pediatr. 2021 Jun 4;237:197–205.e4. doi: 10.1016/j.jpeds.2021.05.059

Table 8; online.

Frequencies of neurodevelopmental outcomes by neonatal cranial ultrasound finding defining white matter damage as cerebral echolucency, cerebral echodensity, or moderate to severe ventriculomegaly; IVH – intraventricular hemorrhage.

Ultrasound findings Percent (Ns)
Outcome Neither IVH nor WMD IVH without WMD WMD without IVH IVH and WMD
Cerebral palsy 5 (34) 9 (7) 23 (18) 31 (34)
Gross motor function classification system level > 0 2 (14) 3 (2) 13 (10) 16 (18)
Epilepsy 4 (27) 10 (8) 18 (14) 15 (17)
Pediatric quality of life < 70 20 (123) 19 (15) 38 (28) 47 (48)
Neurodevelopmental burden
 No cognitive impairment, cerebral palsy, ASD, or epilepsy 75 (466) 65 (52) 39 (30) 48 (53)
 No cognitive impairment; one or more of: cerebral palsy, ASD, or epilepsy 6 (40) 8 (6) 19 (15) 12 (13)
 Cognitive impairment* 19 (115) 28 (22) 42 (32) 41 (45)
TOTAL 621 80 77 111
*

Cognitive impairment is LPA score indicating moderate or severe impairment.

Abbreviations: WMD - White matter injury defined as cerebral echolucency, cerebral echodensity, or moderate to severe ventriculomegaly; IVH – intraventricular hemorrhage