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. 2021 Jul 7;30(5):619–634. doi: 10.1007/s11248-021-00271-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — Cytotoxicity of PBMCs, AECs, and CECs from GTKO, TKO, and WT pigs. a The cytotoxicity of GTKO pigs on PBMCs was significantly lower than that on WT pigs at 60, 90, and 120 min (**P < 0.01; ***P < 0.001 vs. WT), and there was further significant reduction in the cytotoxicity of TKO pig compared to that of GTKO or WT pigs (**P < 0.01; ***P < 0.001) at all time points. b The cytotoxicity of transgenic pigs on AECs was significantly decreased compared to that of WT pigs at all time points (**P < 0.01; ***P < 0.001 vs. WT), but there was no difference in cytotoxicity between GTKO and TKO pig AECs. c The cytotoxicity of transgenic pigs on CECs was significantly reduced from WT at 300 min (*P < 0.05; ***P < 0.001 vs. WT), but there was similar cytotoxicity between GTKO and TKO pigs. Experiments were performed in quadruplicate.