Skip to main content
. 2021 Aug 21;38(10):5412–5423. doi: 10.1007/s12325-021-01877-6
Ciprofol is a new anesthetic 2,6-disubstituted phenolic derivative, which binds to the gamma-aminobutyric acid-A (GABAA) receptor as does propofol.
Ciprofol has a stronger affinity for the GABAA receptor and produces greater GABAA-mediated cell currents in vitro.
A phase 1 study suggested potential clinical advantages of ciprofol as a sedation/anesthetic agent, with no evidence of drug-related toxicity.
Ciprofol might be effective as anesthetic agent for Chinese intensive care unit patients receiving mechanical ventilation requiring endotracheal intubation.