We found controlled studies for only nine out of 87 medications of interest; 21 randomized controlled trials provided data on 1768 participants.

Second-generation antipsychotics, anticonvulsants, and antidepressants were not able to consistently reduce the severity of borderline personality disorder.

Low- and very-low-certainty evidence indicates that anticonvulsants can improve anger, aggression, and affective lability, however, the evidence is mostly limited to single studies.