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. 2021 Sep 28;38(11):133. doi: 10.1007/s12032-021-01584-w

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© The Author(s) 2021

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Fig. 2 — Polyaneuploid cancer cells utilize LDs to protect from lipotoxicity. Chemotherapy is applied to a cancer cell. Surviving cancer cells can become a PACC that is filled with free fatty acids due to the potential upregulation of lipid synthesis and fatty acid synthesis. If free fatty acids are able to be sequestered in LDs, the PACC is able to survive. If the PACC cannot produce LDs and sequester free fatty acids, the PACC will die due to lipotoxicity