Table 3.
Healthcare resource utilization before and after initiation of aripiprazole lauroxil, in patient cohorts stratified by recent antipsychotic usage
| Recent antipsychotic use | All Patients (N = 485) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| LAI (N = 217) | Oral (N = 195) | None (N = 73) | ||||||||||
| 6-month pre-period | Follow-up period | P value | 6-month pre-period | Follow-up period | P value | 6-month pre-period | Follow-up period | P value | 6-month pre-period | Follow-up period | P value | |
| Mental health relateda | ||||||||||||
| Inpatient admissions | ||||||||||||
| Patients with an admission, n (%) | 56 (25.8) | 58 (26.7) | 0.800 | 66 (33.8) | 43 (22.1) | 0.002 | 13 (17.8) | 10 (13.7) | 0.405 | 135 (27.8) | 111 (22.9) | 0.037 |
| Admissions per patient, mean (SD) | 0.5 (1.2) | 0.4 (0.9) | 0.288 | 0.6 (1.3) | 0.5 (1.3) | 0.046 | 0.4 (1.0) | 0.2 (0.6) | 0.096 | 0.6 (1.2) | 0.4 (1.1) | 0.011 |
| Length of stay per admission, mean (SD) | 2.0 (4.0) | 2.6 (5.6) | 0.123 | 3.4 (6.3) | 2.1 (5.6) | 0.010 | 3.0 (8.9) | 1.1 (3.1) | 0.067 | 2.7 (5.9) | 2.2 (5.3) | 0.083 |
| OP visits and servicesa | ||||||||||||
| Patients with an OP service or visit, n (%) | 215 (99.1) | 214 (98.6) | 0.564 | 194 (99.5) | 193 (99.0) | 0.564 | 73 (100) | 72 (98.6) | N/A | 482 (99.4) | 479 (98.8) | 0.257 |
| OP service or visit per patient, mean (SD) | 61.9 (71.2) | 61.9 (71.5) | 0.984 | 49.6 (66.1) | 52.7 (72.8) | 0.165 | 29.7 (30.8) | 33.5 (38.9) | 0.355 | 52.1 (65.4) | 53.9 (68.7) | 0.213 |
| Patients with an ER visit, n (%) | 78 (35.9) | 76 (35.0) | 0.785 | 93 (47.7) | 73 (37.4) | 0.014 | 23 (31.5) | 19 (26.0) | 0.285 | 194 (40.0) | 168 (34.6) | 0.025 |
| ER visits per patient, mean (SD) | 4.4 (13.7) | 4.4 (11.9) | 0.945 | 4.3 (9.5) | 4.4 (12.5) | 0.953 | 2.8 (7.0) | 3.8 (11.0) | 0.320 | 4.1 (11.3) | 4.3 (12.0) | 0.665 |
| OP prescriptions | ||||||||||||
| OP prescriptions per patient, mean (SD) | 20.3 (14.4) | 20.2 (13.3) | 0.755 | 17.1 (11.7) | 20.9 (14.1) | < 0.001 | 7.1 (7.9) | 12.5 (10.7) | < 0.001 | 17.1 (13.3) | 19.3 (13.6) | < 0.001 |
| All-cause | ||||||||||||
| Inpatient admissions | ||||||||||||
| Patients with an admission, n (%) | 59 (27.2) | 65 (30.0) | 0.480 | 72 (36.9) | 51 (26.2) | 0.007 | 15 (20.5) | 12 (16.4) | 0.467 | 146 (30.1) | 128 (26.4) | 0.142 |
| Admissions per patient, mean (SD) | 0.6 (1.5) | 0.6 (1.2) | 0.475 | 0.7 (1.3) | 0.5 (1.3) | 0.027 | 0.4 (1.1) | 0.3 (0.6) | 0.159 | 0.6 (1.4) | 0.5 (1.2) | 0.017 |
| Length of stay per admission, mean (SD) | 2.0 (3.9) | 2.7 (5.5) | 0.082 | 3.7 (6.7) | 2.3 (5.6) | 0.004 | 3.2 (9.0) | 1.2 (3.3) | 0.079 | 2.9 (6.1) | 2.3 (5.3) | 0.071 |
| OP services and visitsa | ||||||||||||
| Patients with an OP service or visit, n (%) | 216 (99.5) | 214 (98.6) | 0.157 | 194 (99.5) | 193 (99.0) | 0.564 | 73 (100) | 72 (98.6) | N/A | 483 (99.6) | 479 (98.8) | 0.102 |
| OP service or visit per patient, mean (SD) | 85.7 (84.8) | 84.5 (86.3) | 0.683 | 70.2 (75.6) | 71.3 (80.6) | 0.718 | 45.7 (46.0) | 55.0 (71.2) | 0.166 | 73.4 (77.5) | 74.7 (82.4) | 0.532 |
| Patients with an ER visit, n (%) | 98 (45.2) | 98 (45.2) | 1.000 | 105 (53.8) | 87 (44.6) | 0.029 | 28 (38.4) | 28 (38.4) | 1.000 | 231 (47.6) | 213 (43.9) | 0.136 |
| ER visits per patient, mean (SD) | 7.7 (22.8) | 8.5 (20.2) | 0.402 | 7.5 (16.6) | 7.6 (19.3) | 0.926 | 7.0 (16.7) | 9.6 (32.5) | 0.348 | 7.5 (19.6) | 8.3 (22.1) | 0.275 |
| OP prescriptions | ||||||||||||
| OP prescriptions per patient, mean (SD) | 37.0 (31.5) | 37.5 (33.3) | 0.550 | 33.0 (28.8) | 38.2 (29.8) | < 0.001 | 16.3 (17.1) | 25.5 (23.1) | < 0.001 | 32.3 (29.5) | 36.0 (30.8) | < 0.001 |
Statistically significant values are in bold
ER emergency room, LAI long-acting injectable, N/A not applicable, OP outpatient, SD standard deviation
aOP visits and services include physician office visits, laboratory tests, radiology tests, and other miscellaneous healthcare services performed in an OP setting. ER visits that do not result in an inpatient admission are also a subcategory of OP service