Table 1.

The Physical Characterization of the Nanoparticles

Formulations	Particle Size (nm)	Zeta Potential (mV)	PDI	LC(%)	EE(%)
Blank-NPs	235.1 ± 6.86	−14.6 ± 0.4	0.126 ± 0.03	–	–
LVFX-NPs	237.93 ± 8.36	−16.83 ± 0.31	0.227 ± 0.04	3.7 ± 0.38	67 ± 2.67
BM2-Blank-NPs	271.3 ± 6.05	−16.9 ± 0.69	0.139 ± 0.06	–	–
BM2-LVFX-NPs	273.9 ± 1.14	−18.33 ± 0.778	0.153 ± 0.03	3.9 ± 0.46	65.59 ± 3.28

Abbreviations: Blank-NPs, water-loaded PLGA-PEG nanoparticles; LVFX-NPs, LVFX-loaded PLGA-PEG nanoparticles; BM2-Blank-NPs, BM2 aptamer modified Blank-loaded PLGA-PEG nanoparticles; BM2-LVFX-NPs, BM2 aptamer modified LVFX-loaded PLGA-PEG nanoparticles; PDI, polydispersity index; LC, loading content; EE, encapsulation efficiency.