Table 3.

Reduced White Matter Volume Associated with Childhood Blood Concentrations at Age 78 Months

Anatomical Region	Cluster Size (Voxels)	Peak Voxel MNI Coordinates (X,Y,Z)	Peak Voxel TFCE	Voxel P-Value
Cingulate Inferior Frontal Gyrus Medial Frontal Gyrus Middle Frontal Gyrus Orbital Gyrus Superior Frontal Gyrus	4361	−5 45 −15	8123.55	0.034
Cingulate Cuneus Inferior Parietal Lobule Insula Medial Frontal Gyrus Middle Occipital Gyrus Postcentral Gyrus Precentral Gyrus Precuneus Superior Temporal Gyrus	26652	35 −29 26	12690.48	0.01
Subcallosal Gyrus	132	11 15 −17	7202.14	0.046
Inferior Frontal Gyrus Medial Frontal Gyrus	423	12 38 −15	7218.73	0.046
Medial Frontal Gyrus Superior Frontal Gyrus	286	20 50 9	7199.75	0.047
Cingulate Inferior Parietal Lobule Middle Occipital Gyrus Postcentral Gyrus Precentral Gyrus Precuneus Supramarginal Gyrus	6013	−26 −63 41	8764.15	0.029
Cingulate Medial Frontal Gyrus Supplemental Motor Area	926	−17 −7 53	7259.18	0.045

Model adjusted for age at time of imaging, birth weight and total intracranial volume. Voxels and clusters corrected for multiple comparisons (FWE) at P ≤ 0.05 using TFCE. FWE = Familywise Error Rate; MNI = Montreal Neurological Institute; TFCE = Threshold Free Cluster Enhancement