Table 2:
Association of Baseline Laboratory and Clinical Variables with Hyperfiltration
| All Sickle Cell Disease | Test for Interaction† |
HbSS/HbSβ°-Thalassemia | HbSC/HbSβ+-Thalassemia | ||||
|---|---|---|---|---|---|---|---|
| Variable | OR (95% CI) | p | p | OR (95% CI) | p | OR (95% CI) | p |
| Age | 0.87 (0.85 - 0.90) | <0.0001 | 0.20 | 0.85 (0.81 - 0.89) | <0.0001 | 0.89 (0.84 - 0.95) | 0.0003 |
| Male sex | 0.43 (0.26 - 0.68) | 0.0004 | 0.16 | 0.49 (0.27 - 0.87) | 0.01 | 0.20 (0.07 - 0.61) | 0.005 |
| White blood cell count | 1.08 (0.99 - 1.17) | 0.07 | 0.028 | 0.95 (0.84 - 1.06) | 0.3 | 1.17 (0.97 - 1.40) | 0.1 |
| Hemoglobin | 0.73 (0.62- 0.86) | 0.0001 | 0.29 | 1.03 (0.80 - 1.32) | 0.8 | 0.80 (0.50 - 1.29) | 0.4 |
| Reticulocyte count* | 1.05 (1.02 - 1.08) | 0.002 | 0.15 | 1.00 (0.97 - 1.04) | 0.9 | 1.07 (0.96 - 1.18) | 0.2 |
| Hemoglobin F | 1.03 (0.96 -1.10) | 0.5 | 0.096 | 0.99 (0.91 - 1.08) | 0.9 | 0.64 (0.35 - 1.18) | 0.1 |
| Ferritin* | 1.00 (1.00 - 1.01) | 0.3 | 0.0054 | 1.00 (1.00 - 1.00) | 0.7 | 1.08 (1.00 - 1.17) | 0.04 |
| Lactate dehydrogenase* | 1.01 (1.00 - 1.02) | 0.03 | 0.0040 | 1.00 (0.99 - 1.01) | 0.5 | 1.04 (1.01 - 1.07) | 0.02 |
| Total bilirubin | 1.36 (1.13 - 1.63) | 0.0009 | 0.81 | 1.16 (0.94 - 1.43) | 0.2 | 1.10 (0.48 - 2.56) | 0.8 |
| Direct bilirubin | 0.51 (0.01 - 29.64) | 0.7 | 0.88 | 2.19 (0.00 - 1000.00) | 0.9 | N/A | |
| Indirect bilirubin | 1.78 (0.98 - 3.25) | 0.06 | 0.51 | 1.61 (0.67 - 3.87) | 0.3 | 0.42 (0.02 - 7.59) | 0.6 |
| Hemoglobinuria | 0.34 (0.10 - 1.63) | 0.2 | *** | 0.18 (0.04 - 0.83) | 0.03 | *** | |
| Proteinuria | 0.76 (0.25 - 2.34) | 0.6 | 0.41 | 0.41 (0.12 - 1.44) | 0.2 | 1.71 (0.04 - 68.46) | 0.8 |
| Systolic blood pressure* | 0.80 (0.65 – 0.98) | 0.03 | 0.39 | 0.85 (0.66 - 1.10) | 0.2 | 1.02 (0.67 - 1.56) | 0.9 |
| Diastolic blood pressure* | 0.77 (0.61 - 0.97) | 0.02 | 0.26 | 0.78 (0.60 - 1.02) | 0.07 | 1.08 (0.67 - 1.73) | 0.7 |
| Weight | 0.95 (0.93 - 0.97) | <0.0001 | 0.31 | 0.96 (0.93 - 0.99) | 0.004 | 0.98 (0.95 - 1.01 | 0.2 |
| Height | 1.03 (0.97 - 1.11) | 0.3 | 0.38 | 1.07 (0.96 - 1.19) | 0.2 | 0.96 (0.84 - 1.09) | 0.5 |
| History of diabetes | 0.83 (0.13 - 5.13) | 0.8 | 0.97 | 2.33 (0.25 - 21.43) | 0.5 | N/A | |
| History of stroke | 0.83 (0.32 - 2.16) | 0.7 | 0.39 | 0.46 (0.14 - 1.49) | 0.2 | 1.42 (0.15 - 13.42) | 0.8 |
| History of acute chest syndrome | 2.52 (1.11 - 5.71) | 0.03 | 0.38 | 0.91 (0.23 - 3.59) | 0.9 | 1.72 (0.46 - 6.50) | 0.4 |
| History of avascular necrosis | 0.94 (0.43 - 2.05) | 0.9 | 0.13 | 0.40 (0.14 - 1.17) | 0.1 | 1.85 (0.33 - 10.45) | 0.5 |
| History of leg ulcers | 0.87 (0.30 - 2.53) | 0.8 | 0.99 | 0.53 (0.16 - 1.80) | 0.3 | N/A | |
| ACEi/ARB therapy | 0.21 (0.05 - 0.92) | 0.04 | 0.91 | 0.19 (0.03 - 1.13) | 0.07 | 0.26 (0.02 - 3.72) | 0.3 |
| Hydroxyurea therapy | 1.95 (1.02 - 3.73) | 0.04 | 0.69 | 1.33 (0.60 - 2.98) | 0.5 | 1.78 (0.40 - 8.02) | 0.5 |
| Chronic RBC transfusion | 0.53 (0.11 - 2.51) | 0.4 | 0.98 | 0.29 (0.05 - 1.80) | 0.2 | N/A | |
ACE-I = angiotensin-converting enzyme inhibitor; ARB = angiotensin receptor blocker; RBC = red blood cell
For continuous variables Odds Ratios (OR) are for a one unit change.
All variables (except age and sex) adjusted for age and sex.
*
OR presented per 10 unit change
***
model did not converge given low number of events
†
Testing for interaction with genotype severity was performed for each variable of interest adjusting for baseline age and sex.