Table 4:

Multivariable Model for Hyperfiltration at Baseline in Adults with Sickle Cell Disease

	All Sickle Cell Disease		HbSS/HbSβ° Thalassemia		HbSC/HbSβ+ Thalassemia
Variable	Odds Ratio (95% CI)	p	Odds Ratio (95% CI)	p	Odds Ratio (95% CI)	p
Age	0.86 (0.82 – 0.90)	< 0.0001	0.81 (0.75 – 0.87)	<0.0001	0.93 (0.87 – 0.99)	0.03
Male Sex	0.16 (0.07 – 0.41)	0.0001	0.13 (0.04 – 0.50)	0.003	0.08 (0.02 – 0.46)	0.004
Hemoglobin	0.76 (0.61 – 0.94)	0.01
Weight	0.96 (0.93 – 0.99)	0.004	0.94 (0.89 – 0.99)	0.01
Hydroxyurea Therapy	2.99 (1.18 – 7.56)	0.02
Use of ACE-I/ARBs	0.08 (0.01 – 0.75)	0.03	0.07 (0.01 – 0.82)	0.03
Lactate Dehydrogenase			0.998 (0.997 – 1.000)	0.03

ACE-I = angiotensin-converting enzyme inhibitor; ARB = angiotensin receptor blocker

For continuous variables Odds Ratios (OR) are for a one unit change.

Results from multivariable logistic regression with backward elimination for variable selection. Variables initially assessed for inclusion in the model: white blood cell count, hemoglobin, reticulocyte count, lactate dehydrogenase, total bilirubin, hydroxyurea therapy, weight, systolic blood pressure, diastolic blood pressure, acute chest syndrome, and ACE inhibitor/ARB therapy. The model was adjusted for age and sex.