Table 4 -.

Association of baseline plasma ceramides with risk of incident T2DM.

Ceramides	Incident T2DM Hazard ratio (95% CI) n = 37/1128 Model 1	P value	Incident T2DM Hazard ratio (95% CI) n = 37/1128 Model 2	P value
C14:0	0.90 (0.62 – 1.30)	0.56	0.92 (0.63 – 1.33)	0.65
C16:0	0.74 (0.51 – 1.09)	0.13	0.78 (0.53 – 1.16)	0.22
C18:0	1.49 (1.10 – 2.01)	0.01	1.53 (1.12 – 2.08)	0.01
C18:1	0.97 (0.68 – 1.39)	0.88	1.01 (0.71 – 1.44)	0.97
C20:0	1.20 (0.87 – 1.66)	0.27	1.26 (0.90 – 1.75)	0.18
C23:0	1.02 (0.74 – 1.42)	0.90	1.07 (0.78 – 1.47)	0.69
C24:0	0.91 (0.65 – 1.28)	0.59	0.98 (0.70 – 1.39)	0.92
C24:1	1.00 (0.71 – 1.39)	0.97	1.05 (0.75 – 1.47)	0.79
C16:0/24:0	0.87 (0.54 – 1.40)	0.57	0.84 (0.52 – 1.36)	0.48
C18:0/16:0	1.63 (1.27 – 2.10)	<0.001	1.63 (1.26 – 2.10)	<0.001
C18:0/24:0	1.19 (1.01 – 1.40)	0.04	1.15 (0.97 – 1.36)	0.11
C24:1/24:0	1.05 (0.83 – 1.33)	0.69	1.02 (0.80 – 1.29)	0.88

Cox proportional hazard ratio (95% confidence interval) for risk of incident T2DM per standard deviation (SD) increment in z-score of ceramides.

Model 1: adjusted for age and sex.

Model 2: additionally adjusted for hypertension, dyslipidemia, and vascular burden.