Fig. 1.

Effects of STAT3 inhibitors on mitochondrial function. DU-145 cells were treated with the indicated STAT3 inhibitors at 30 uM for 2 Hrs. Seahorse experiments showing oxygen consumption rate (OCR) by DU-145 cells treated with DMSO alone or DMSO containing the indicated STAT3 inhibitor at 30uM prior to and following addition of oligomycin, FCCP, and antimycin A/rotenone, as indicated (n = 6). Data in (Fig. 1 A) combined into one graph, showing all the OCR curves relative to each other. Below, figure representing estimation of OCR parameters in(C) Mean ± SEM of basal respiration, maximal respiration, spare respiratory capacity, ATP production, coupling efficiency and proton leak (n = 6).