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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Biochem Pharmacol. 2021 Jul 16;192:114688. doi: 10.1016/j.bcp.2021.114688

Fig. 6.

Fig. 6.

TTI-101 does not cause mechanical allodynia; rather, it reverses mechanical allodynia caused by cisplatin. A. Male C57/Bl6 mice (n = 8 per group) received TTI-101 (50 mg/kg i.p. every other day) and mechanical allodynia was assessed using von Frey hairs and the up-and-down method. B. Male C57/Bl6 mice (n = 4 per group) were treated with cisplatin (two rounds of 5 daily doses of 2.3 mg/kg i.p. followed by 5 days of rest). Dosing with TTI-101 (50 mg/kg i.p. every other day) started 17 days after the last dose of cisplatin. Data were analyzed by two-way ANOVA repeated measures. Time: P < 0.001; Group: P < 0.001; Interaction P < 0.001. **P < 0.01 Tukey multiple comparison test.