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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Biochem Pharmacol. 2021 Jul 16;192:114688. doi: 10.1016/j.bcp.2021.114688

Table 1.

Details on the overlapping genes that were altered in both groups, PBS vs Cis, and Cis vs Cis + TTI-101.

Symbol Entrez Gene Name Location PBS vs Cis Cis vs Cis + TTI-101


log2 Fold Expr p-value log2 Fold Expr p-value

1 6530402F18Rik RIKEN cDNA 6530402F18 gene Other −0.27 0.07 −0.44 0.02
2 ABCA2 ATP binding cassette subfamily A member 2 Plasma Membrane 0.23 0.01 −0.42 0.04
3 ABCA3 ATP binding cassette subfamily A member 3 Plasma Membrane 0.28 0.00 −0.32 0.06
4 ABCA7 ATP binding cassette subfamily A member 7 Plasma Membrane 0.24 0.01 −0.36 0.03
5 ABCG4 ATP binding cassette subfamily G member 4 Plasma Membrane 0.24 0.00 −0.32 0.04
6 ABHD17A abhydrolase domain containing 17A Plasma Membrane −0.23 0.00 −0.35 0.00
7 ABHD8 abhydrolase domain containing 8 Cytoplasm −0.27 0.00 −0.21 0.06
8 ACACB acetyl-CoA carboxylase beta Cytoplasm 0.30 0.02 −0.30 0.04
9 ADAMTSL2 ADAMTS like 2 Extracellular Space 0.37 0.02 −0.31 0.08
10 ADAP1 ArfGAP with dual PH domains 1 Nucleus −0.22 0.00 −0.23 0.05
11 ADCK2 aarF domain containing kinase 2 Cytoplasm 0.20 0.05 −0.30 0.02
12 AEBP1 AE binding protein 1 Nucleus 0.60 0.00 −0.23 0.08
13 AKNA AT-hook transcription factor Nucleus 0.54 0.00 −0.41 0.03
14 ALAD aminolevulinate dehydratase Cytoplasm 0.30 0.01 −0.43 0.01
15 ALDH2 aldehyde dehydrogenase 2 family member Cytoplasm 0.23 0.00 −0.34 0.02
16 ALDH4A1 aldehyde dehydrogenase 4 family member A1 Cytoplasm 0.35 0.00 −0.29 0.05
17 ALOX5 arachidonate 5-lipoxygenase Cytoplasm 0.76 0.00 −0.38 0.07
18 AMBRA1 autophagy and beclin 1 regulator 1 Cytoplasm 0.22 0.01 −0.32 0.02
19 AMOTL2 angiomotin like 2 Plasma Membrane 0.24 0.00 −0.31 0.01
20 AMPD2 adenosine monophosphate deaminase 2 Cytoplasm 0.24 0.00 −0.25 0.07
21 AMPD3 adenosine monophosphate deaminase 3 Cytoplasm 0.26 0.00 −0.21 0.08
22 ANKRD13B ankyrin repeat domain 13B Plasma Membrane −0.26 0.01 −0.28 0.05
23 ANO1 anoctamin 1 Plasma Membrane 0.36 0.01 −0.33 0.04
24 AP5Z1 adaptor related protein complex 5 subunit zeta 1 Nucleus 0.24 0.01 −0.27 0.04
25 ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domaino Cytoplasm 0.36 0.00 −0.24 0.07
26 ARHGEF10L Rho guanine nucleotide exchange factor 10 like Cytoplasm −0.34 0.00 −0.28 0.05
27 ARHGEF2 Rho/Rac guanine nucleotide exchange factor 2 Cytoplasm 0.28 0.00 −0.22 0.05
28 ARID3A AT-rich interaction domain 3A Nucleus 0.29 0.05 −0.29 0.05
29 ARMC7 armadillo repeat containing 7 Cytoplasm 0.22 0.07 −0.35 0.02
30 ARMH3 armadillo like helical domain containing 3 Other 0.25 0.00 −0.28 0.09
31 ARRDC1 arrestin domain containing 1 Cytoplasm 0.22 0.01 −0.20 0.08
32 ATP1B2 ATPase Na+/K + transporting subunit beta 2 Plasma Membrane 0.25 0.00 −0.42 0.01
33 ATP2A3 ATPase sarcoplasmic/endoplasmic reticulum Ca2 + transporting 3 Cytoplasm 0.53 0.00 −0.49 0.00
34 ATP2B2 ATPase plasma membrane Ca2 + transporting 2 Plasma Membrane 0.39 0.00 −0.45 0.02
35 ATP6V1G2 ATPase H + transporting V1 subunit G2 Cytoplasm 0.23 0.00 −0.31 0.01
36 B230206H07Rik RIKEN cDNA B230206H07 gene Other 0.59 0.00 −0.38 0.07
37 BAG3 BCL2 associated athanogene 3 Cytoplasm −0.27 0.00 −0.38 0.01
38 BCAR1 BCAR1 scaffold protein, Cas family member Plasma Membrane −0.23 0.03 −0.31 0.05
39 BCOR BCL6 corepressor Nucleus 0.28 0.00 −0.21 0.07
40 BRD3 bromodomain containing 3 Nucleus 0.34 0.00 −0.26 0.06
41 BRPF3 bromodomain and PHD finger containing 3 Cytoplasm 0.26 0.00 −0.22 0.05
42 C11orf24 chromosome 11 open reading frame 24 Extracellular Space 0.32 0.00 −0.31 0.08
43 C11orf98 chromosome 11 open reading frame 98 Other −0.24 0.03 0.25 0.04
44 C15orf39 chromosome 15 open reading frame 39 Cytoplasm 0.37 0.05 −0.50 0.03
45 C1QC complement C1q C chain Extracellular Space −0.38 0.01 0.52 0.01
46 C3AR1 complement C3a receptor 1 Plasma Membrane −0.44 0.06 0.63 0.02
47 CACHD1 cache domain containing 1 Other 0.22 0.02 −0.29 0.08
48 CACNG5 calcium voltage-gated channel auxiliary subunit gamma 5 Plasma Membrane 0.41 0.00 −0.47 0.02
49 CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase Cytoplasm 0.22 0.03 −0.49 0.01
50 CAMK2B calcium/calmodulin dependent protein kinase II beta Cytoplasm 0.23 0.00 −0.28 0.03
51 CARMIL2 capping protein regulator and myosin 1 linker 2 Plasma Membrane −0.29 0.00 −0.32 0.02
52 CASP1 caspase 1 Cytoplasm −0.36 0.06 0.33 0.06
53 CASR calcium sensing receptor Plasma Membrane −0.36 0.09 0.33 0.07
54 CBLL1 Cbl proto-oncogene like 1 Nucleus 0.24 0.02 −0.30 0.07
55 CCDC88B coiled-coil domain containing 88B Nucleus 0.40 0.09 −0.44 0.08
56 CCDC88C coiled-coil domain containing 88C Cytoplasm 0.88 0.00 −0.44 0.04
57 CCDC92B coiled-coil domain containing 92B Other −0.28 0.00 −0.31 0.03
58 CCN2 cellular communication network factor 2 Extracellular Space 0.36 0.03 −0.34 0.08
59 CDC42EP3 CDC42 effector protein 3 Cytoplasm 0.25 0.04 −0.30 0.02
60 CEP250 centrosomal protein 250 Nucleus 0.22 0.00 −0.21 0.07
61 CHD4 chromodomain helicase DNA binding protein 4 Nucleus 0.23 0.00 −0.24 0.08
62 CHD5 chromodomain helicase DNA binding protein 5 Nucleus 0.21 0.00 −0.35 0.01
63 CHERP calcium homeostasis endoplasmic reticulum protein Cytoplasm 0.24 0.01 −0.43 0.00
64 CHIC2 cysteine rich hydrophobic domain 2 Plasma Membrane −0.21 0.07 0.23 0.08
65 CHPF chondroitin polymerizing factor Cytoplasm −0.28 0.00 −0.24 0.05
66 CHST2 carbohydrate sulfotransferase 2 Cytoplasm −0.25 0.00 −0.31 0.01
67 CIART circadian associated repressor of transcription Nucleus 0.53 0.02 0.37 0.04
68 CISD3 CDGSH iron sulfur domain 3 Cytoplasm −0.23 0.00 0.21 0.04
69 CITED2 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 Nucleus 0.24 0.03 −0.27 0.05
70 CLIP2 CAP-Gly domain containing linker protein 2 Cytoplasm −0.21 0.01 −0.33 0.03
71 CLSTN2 calsyntenin 2 Plasma Membrane 0.21 0.00 −0.26 0.08
72 CLSTN3 calsyntenin 3 Plasma Membrane 0.22 0.01 −0.29 0.07
73 CLUH clustered mitochondria homolog Cytoplasm 0.40 0.00 −0.41 0.03
74 CNTN2 contactin 2 Plasma Membrane 0.24 0.00 −0.41 0.02
75 CNTROB centrobin, centriole duplication and spindle assembly protein Cytoplasm 0.28 0.01 −0.27 0.05
76 COBLL1 cordon-bleu WH2 repeat protein like 1 Extracellular Space 0.25 0.03 −0.27 0.02
77 COL6A3 collagen type VI alpha 3 chain Extracellular Space 0.43 0.00 −0.25 0.08
78 COMP cartilage oligomeric matrix protein Extracellular Space 0.39 0.00 −0.31 0.06
79 CORO6 coronin 6 Extracellular Space 0.25 0.02 −0.24 0.07
80 CORO7/CORO7-PAM16 coronin 7 Cytoplasm 0.32 0.00 −0.29 0.07
81 CPB1 carboxypeptidase B1 Extracellular Space −0.26 0.04 0.26 0.06
82 CPSF1 cleavage and polyadenylation specific factor 1 Nucleus 0.54 0.00 −0.30 0.07
83 CRIP1 cysteine rich protein 1 Cytoplasm −0.29 0.00 0.29 0.04
84 CRMP1 collapsin response mediator protein 1 Cytoplasm 0.27 0.00 −0.27 0.07
85 CRTC2 CREB regulated transcription coactivator 2 Nucleus 0.21 0.00 −0.27 0.01
86 CSDC2 cold shock domain containing C2 Cytoplasm 0.20 0.03 −0.46 0.01
87 CSF3R colony stimulating factor 3 receptor Plasma Membrane 0.63 0.00 −0.46 0.07
88 CSMD2 CUB and Sushi multiple domains 2 Other 0.25 0.03 −0.33 0.01
89 CSNK1G2 casein kinase 1 gamma 2 Cytoplasm −0.23 0.00 −0.24 0.04
90 CSRNP1 cysteine and serine rich nuclear protein 1 Nucleus 0.32 0.07 −0.44 0.02
91 CTSE cathepsin E Cytoplasm 1.04 0.02 −0.65 0.00
92 Cuxl cut-like homeobox 1 Nucleus 0.24 0.00 −0.28 0.03
93 CX3CL1 C-X3-C motif chemokine ligand 1 Extracellular Space 0.33 0.01 −0.33 0.06
94 DAG1 dystroglycan 1 Plasma Membrane 0.21 0.00 −0.48 0.01
95 DAP death associated protein Cytoplasm 0.21 0.02 −0.23 0.03
96 DDX19A DEAD-box helicase 19A Nucleus 0.23 0.02 −0.24 0.06
97 DGCR2 DiGeorge syndrome critical region gene 2 Plasma Membrane 0.20 0.00 −0.27 0.08
98 DGKD diacylglycerol kinase delta Cytoplasm 0.23 0.01 −0.21 0.07
99 DHX34 DExH-box helicase 34 Other 0.24 0.02 −0.33 0.06
100 DIO2 iodothyronine deiodinase 2 Cytoplasm −0.47 0.04 −0.59 0.01
101 DISP1 dispatched RND transporter family member 1 Plasma Membrane 0.28 0.00 −0.22 0.06
102 DLC1 DLC1 Rho GTPase activating protein Cytoplasm 0.24 0.00 −0.30 0.07
103 DLGAP3 DLG associated protein 3 Cytoplasm −0.28 0.01 −0.36 0.05
104 DNAJC15 DnaJ heat shock protein family (Hsp40) member C15 Cytoplasm −0.22 0.02 0.21 0.09
105 DNM1 dynamin 1 Cytoplasm −0.22 0.03 −0.27 0.09
106 DNMT1 DNA methyltransferase 1 Nucleus 0.38 0.00 −0.24 0.05
107 DOCK1 dedicator of cytokinesis 1 Cytoplasm 0.29 0.00 −0.36 0.02
108 DOCK6 dedicator of cytokinesis 6 Cytoplasm 0.41 0.00 −0.22 0.10
109 DOCK8 dedicator of cytokinesis 8 Cytoplasm 0.45 0.00 −0.30 0.01
110 DOK3 docking protein 3 Cytoplasm 0.48 0.02 −0.43 0.07
111 DOP1B DOP1 leucine zipper like protein B Cytoplasm 0.28 0.01 −0.41 0.03
112 DPYSL4 dihydropyrimidinase like 4 Cytoplasm 0.34 0.00 −0.25 0.02
113 DUS3L dihydrouridine synthase 3 like Other 0.23 0.00 −0.20 0.05
114 DUSP15 dual specificity phosphatase 15 Cytoplasm 0.28 0.01 −0.31 0.05
115 E2F2 E2F transcription factor 2 Nucleus 0.52 0.00 −0.33 0.09
116 EDC4 enhancer of mRNA decapping 4 Cytoplasm 0.43 0.00 −0.25 0.08
117 EFHC1 EF-hand domain containing 1 Cytoplasm −0.29 0.04 0.34 0.03
118 EGR2 early growth response 2 Nucleus 0.28 0.04 −0.52 0.02
119 ELANE elastase, neutrophil expressed Extracellular Space 0.86 0.00 −0.72 0.03
120 ELMO1 engulfment and cell motility 1 Cytoplasm 0.26 0.00 −0.22 0.08
121 EMC1 ER membrane protein complex subunit 1 Plasma Membrane 0.27 0.00 −0.22 0.10
122 EMCN endomucin Extracellular Space −0.22 0.02 0.29 0.03
123 EPHA2 EPH receptor A2 Plasma Membrane 0.30 0.09 −0.43 0.03
124 ERBB2 erb-b2 receptor tyrosine kinase 2 Plasma Membrane 0.26 0.01 −0.35 0.01
125 ERBB3 erb-b2 receptor tyrosine kinase 3 Plasma Membrane 0.26 0.00 −0.27 0.01
126 ERMAP erythroblast membrane associated protein (Scianna blood group) Cytoplasm 1.31 0.00 −0.54 0.06
127 ESS2 ess-2 splicing factor homolog Nucleus 0.28 0.00 −0.22 0.09
128 EXOSC9 exosome component 9 Nucleus −0.20 0.03 0.20 0.09
129 F2RL2 coagulation factor II thrombin receptor like 2 Plasma Membrane −0.23 0.00 0.22 0.04
130 F5 coagulation factor V Extracellular Space 0.76 0.00 −0.45 0.04
131 F630028010Rik RIKEN cDNA F630028O10 gene Other 0.82 0.00 −0.47 0.07
132 FABP7 fatty acid binding protein 7 Cytoplasm −0.55 0.00 −0.28 0.03
133 FAM20A FAM20A golgi associated secretory pathway pseudokinase Extracellular Space 0.35 0.00 −0.31 0.04
134 FAM222B family with sequence similarity 222 member B Nucleus 0.41 0.00 −0.36 0.05
135 FAM234A family with sequence similarity 234 member A Plasma Membrane 0.37 0.00 −0.31 0.02
136 FAM43B family with sequence similarity 43 member B Other −0.25 0.02 −0.35 0.05
137 FARSB phenylalanyl-tRNA synthetase subunit beta Cytoplasm −0.23 0.00 0.22 0.07
138 FAT1 FAT atypical cadherin 1 Plasma Membrane 0.45 0.00 −0.40 0.04
139 FBLN1 fibulin 1 Extracellular Space 0.40 0.00 −0.34 0.02
140 FBLN7 fibulin 7 Extracellular Space 0.35 0.01 −0.31 0.08
141 FBXO42 F-box protein 42 Other 0.21 0.00 −0.28 0.07
142 FERMT3 fermitin family member 3 Cytoplasm 0.67 0.00 −0.48 0.06
143 FGGY FGGY carbohydrate kinase domain containing Other −0.22 0.04 0.24 0.07
144 FICD FIC domain containing Nucleus 0.24 0.00 −0.39 0.02
145 FLOT1 flotillin 1 Plasma Membrane 0.25 0.00 −0.25 0.07
146 FLT1 fms related tyrosine kinase 1 Plasma Membrane 0.29 0.00 −0.50 0.00
147 FMN2 formin 2 Cytoplasm −0.24 0.00 −0.26 0.04
148 FMNL3 formin like 3 Cytoplasm 0.26 0.05 −0.25 0.09
149 Folh1 folate hydrolase 1 Plasma Membrane −0.28 0.00 0.28 0.01
150 FRMPD1 FERM and PDZ domain containing 1 Cytoplasm 0.27 0.00 −0.37 0.04
151 FRYL FRY like transcription coactivator Other 0.43 0.00 −0.24 0.09
152 FSCN1 fascin actin-bundling protein 1 Cytoplasm −0.25 0.02 −0.41 0.00
153 GAA glucosidase alpha, acid Cytoplasm 0.35 0.00 −0.40 0.03
154 GAS2L1 growth arrest specific 2 like 1 Cytoplasm −0.32 0.00 −0.27 0.06
155 GATB glutamyl-tRNA amidotransferase subunit B Cytoplasm −0.22 0.02 0.22 0.09
156 GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1 Cytoplasm 0.33 0.00 −0.31 0.10
157 GCN1 GCN1 activator of EIF2AK4 Cytoplasm 0.25 0.01 −0.34 0.06
158 GDF11 growth differentiation factor 11 Extracellular Space −0.25 0.00 −0.21 0.05
159 GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 Plasma Membrane −0.25 0.00 −0.22 0.03
160 GLRX glutaredoxin Cytoplasm −0.20 0.01 0.22 0.06
161 Gm12696 predicted gene 12,696 Other −0.39 0.00 0.27 0.08
162 Gm16907 predicted gene, 16,907 Other 0.59 0.01 0.45 0.02
163 GNG7 G protein subunit gamma 7 Plasma Membrane 0.23 0.01 −0.38 0.01
164 GPC1 glypican 1 Plasma Membrane −0.20 0.00 −0.23 0.05
165 GPD1 glycerol-3-phosphate dehydrogenase 1 Cytoplasm −0.20 0.03 −0.25 0.02
166 GPR153 G protein-coupled receptor 153 Plasma Membrane −0.25 0.01 −0.26 0.06
167 GRINA glutamate ionotropic receptor NMDA type subunit associated protein 1 Other 0.37 0.00 −0.30 0.07
168 GTF3A general transcription factor IIIA Nucleus 0.29 0.04 −0.29 0.07
169 GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 Cytoplasm 0.33 0.01 −0.27 0.05
170 GYPC glycophorin C (Gerbich blood group) Plasma Membrane 0.37 0.00 −0.39 0.01
171 HCFC1 host cell factor C1 Nucleus 0.32 0.00 −0.39 0.04
172 HCN2 hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 Plasma Membrane −0.35 0.06 −0.33 0.09
173 HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 Plasma Membrane −0.20 0.06 −0.36 0.02
174 HDDC2 HD domain containing 2 Cytoplasm −0.27 0.00 0.22 0.08
175 HELZ helicase with zinc finger Nucleus 0.24 0.01 −0.21 0.09
176 HEMGN hemogen Nucleus 1.31 0.00 −0.69 0.03
177 HGF hepatocyte growth factor Extracellular Space −0.32 0.00 0.28 0.04
178 HHATL hedgehog acyltransferase like Cytoplasm 0.20 0.04 −0.24 0.09
179 HIVEP1 HIVEP zinc finger 1 Nucleus 0.21 0.01 −0.34 0.05
180 HOXA7 homeobox A7 Nucleus 0.25 0.01 −0.35 0.02
181 HOXC10 homeobox C10 Nucleus 0.29 0.01 −0.28 0.04
182 HPS4 HPS4 biogenesis of lysosomal organelles complex 3 subunit 2 Cytoplasm 0.30 0.00 −0.28 0.04
183 HSP90AA1 heat shock protein 90 alpha family class A member 1 Cytoplasm −0.26 0.00 0.21 0.07
184 Ifi27 interferon, alpha-inducible protein 27 Cytoplasm −0.23 0.00 0.22 0.03
185 Ifi27l2a/Ifi27l2b interferon, alpha-inducible protein 27 like 2A Cytoplasm −0.38 0.02 0.70 0.09
186 IFRD2 interferon related developmental regulator 2 Nucleus 0.64 0.00 −0.53 0.01
187 IGLON5 IgLON family member 5 Other −0.23 0.01 −0.32 0.02
188 INCENP inner centromere protein Nucleus 0.61 0.00 −0.38 0.03
189 INPP5E inositol polyphosphate-5-phosphatase E Cytoplasm 0.21 0.01 −0.20 0.08
190 INSRR insulin receptor related receptor Plasma Membrane 0.62 0.01 −0.43 0.04
191 INSYN1 inhibitory synaptic factor 1 Plasma Membrane −0.32 0.00 −0.31 0.05
192 IPO4 importin 4 Nucleus 0.26 0.00 −0.26 0.09
193 IRF2BP1 interferon regulatory factor 2 binding protein 1 Nucleus −0.26 0.01 −0.37 0.03
194 IRF2BPL interferon regulatory factor 2 binding protein like Nucleus −0.25 0.01 −0.30 0.05
195 ITGA2B integrin subunit alpha 2b Plasma Membrane 0.47 0.01 −0.61 0.01
196 ITPR3 inositol 1,4,5-trisphosphate receptor type 3 Cytoplasm 0.33 0.00 −0.43 0.02
197 KCNA1 potassium voltage-gated channel subfamily A member 1 Plasma Membrane 0.22 0.01 −0.31 0.07
198 KIAA1522 KIAA1522 Other −0.21 0.01 −0.30 0.06
199 KIAA1549L KIAA1549 like Cytoplasm 0.20 0.01 −0.53 0.00
200 KMT2D lysine methyltransferase 2D Nucleus 0.20 0.08 −0.24 0.06
201 KNDC1 kinase non-catalytic C-lobe domain containing 1 Plasma Membrane 0.26 0.01 −0.44 0.03
202 LAMA5 laminin subunit alpha 5 Extracellular Space 0.37 0.00 −0.32 0.04
203 LAMC3 laminin subunit gamma 3 Extracellular Space 0.49 0.00 −0.50 0.06
204 LDLR low density lipoprotein receptor Plasma Membrane 0.39 0.00 −0.33 0.08
205 LGALS1 galectin 1 Extracellular Space −0.31 0.00 0.26 0.06
206 LIMK1 LIM domain kinase 1 Cytoplasm −0.29 0.00 −0.28 0.03
207 LITAF lipopolysaccharide induced TNF factor Nucleus 0.24 0.00 −0.20 0.05
208 LOC proline dehydrogenase 1 Cytoplasm 0.23 0.04 0.49 0.01
209 LRP1 LDL receptor related protein 1 Plasma Membrane 0.41 0.00 −0.36 0.01
210 LRRC32 leucine rich repeat containing 32 Plasma Membrane 0.42 0.01 −0.37 0.10
211 LRRK1 leucine rich repeat kinase 1 Cytoplasm 0.27 0.01 −0.22 0.05
212 LRRN3 leucine rich repeat neuronal 3 Extracellular Space −0.22 0.02 0.21 0.07
213 LSM7 Nucleus −0.25 0.02 0.25 0.07
LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated
214 MADD MAP kinase activating death domain Cytoplasm 0.20 0.01 −0.23 0.10
215 MAP3K14 mitogen-activated protein kinase kinase kinase 14 Cytoplasm 0.26 0.09 −0.25 0.09
216 MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 Cytoplasm 0.31 0.00 −0.27 0.01
217 MAP7D1 MAP7 domain containing 1 Cytoplasm −0.22 0.01 −0.25 0.05
218 MAPK7 mitogen-activated protein kinase 7 Cytoplasm 0.23 0.01 −0.32 0.01
219 MARK4 microtubule affinity regulating kinase 4 Cytoplasm −0.23 0.06 −0.33 0.08
220 MAST4 microtubule associated serine/threonine kinase family member 4 Other 0.31 0.01 −0.42 0.03
221 MCC MCC regulator of WNT signaling pathway Cytoplasm 0.29 0.00 −0.21 0.06
222 MDC1 mediator of DNA damage checkpoint 1 Nucleus 0.31 0.00 −0.30 0.04
223 MED15 mediator complex subunit 15 Nucleus 0.36 0.00 −0.37 0.05
224 MEX3D mex-3 RNA binding family member D Nucleus −0.28 0.01 −0.29 0.07
225 MFSD2B major facilitator superfamily domain containing 2B Plasma Membrane 0.76 0.00 −0.32 0.08
226 MMP15 matrix metallopeptidase 15 Extracellular Space −0.28 0.00 −0.44 0.01
227 MMP9 matrix metallopeptidase 9 Extracellular Space 0.86 0.00 −0.80 0.00
228 MPO myeloperoxidase Cytoplasm 1.26 0.00 −0.96 0.03
229 MRC2 mannose receptor C type 2 Plasma Membrane 0.23 0.00 −0.23 0.04
230 MRGPRX4 MAS related GPR family member X4 Plasma Membrane −0.27 0.01 0.26 0.04
231 MRVI1 murine retrovirus integration site 1 homolog Cytoplasm 0.36 0.00 −0.35 0.04
232 MTSS2 MTSS I-BAR domain containing 2 Plasma Membrane −0.31 0.00 −0.38 0.01
233 MXD1 MAX dimerization protein 1 Nucleus 0.40 0.01 −0.35 0.07
234 MYO1D myosin ID Cytoplasm 0.33 0.00 −0.32 0.07
235 MYO1F myosin IF Cytoplasm 0.63 0.00 −0.39 0.06
236 MYO7A myosin VIIA Cytoplasm 0.29 0.00 −0.24 0.08
237 MYPOP Myb related transcription factor, partner of profilin Nucleus −0.25 0.00 −0.29 0.02
238 NAA80 N(alpha)-acetyltransferase 80, NatH catalytic subunit Cytoplasm 0.25 0.00 −0.38 0.01
239 Naip1 (includes others) NLR family, apoptosis inhibitory protein 1 Cytoplasm 0.56 0.01 0.30 0.08
240 NAT8L N-acetyltransferase 8 like Cytoplasm −0.23 0.00 −0.36 0.02
241 NCSTN nicastrin Plasma Membrane 0.30 0.00 −0.25 0.07
242 NDUFA3 NADH:ubiquinone oxidoreductase subunit A3 Cytoplasm −0.21 0.00 0.22 0.06
243 NDUFAF4 NADH:ubiquinone oxidoreductase complex assembly factor 4 Cytoplasm −0.21 0.01 0.20 0.04
244 NECTIN1 nectin cell adhesion molecule 1 Plasma Membrane −0.42 0.00 −0.36 0.07
245 NFAM1 NFAT activating protein with ITAM motif 1 Plasma Membrane 0.81 0.00 −0.43 0.09
246 NFATC1 nuclear factor of activated T cells 1 Nucleus 0.32 0.01 −0.30 0.05
247 NFE2 nuclear factor, erythroid 2 Nucleus 1.09 0.00 −0.61 0.03
248 NLGN2 neuroligin 2 Plasma Membrane −0.25 0.01 −0.32 0.03
249 NLGN3 neuroligin 3 Plasma Membrane 0.33 0.00 −0.34 0.00
250 NMD3 NMD3 ribosome export adaptor Nucleus −0.21 0.01 0.26 0.01
251 NOL6 nucleolar protein 6 Nucleus 0.25 0.00 −0.39 0.05
252 NOTCH2 notch receptor 2 Plasma Membrane 0.31 0.00 −0.27 0.01
253 Nppb natriuretic peptide type B Other −0.40 0.02 0.34 0.05
254 NPTXR neuronal pentraxin receptor Plasma Membrane −0.22 0.01 −0.29 0.08
255 NR1D1 nuclear receptor subfamily 1 group D member 1 Nucleus 0.36 0.01 −0.29 0.02
256 NR4A2 nuclear receptor subfamily 4 group A member 2 Nucleus 0.27 0.03 −0.29 0.09
257 NRSN2 neurensin 2 Plasma Membrane 0.58 0.00 −0.38 0.07
258 NRXN2 neurexin 2 Plasma Membrane −0.26 0.01 −0.32 0.06
259 NUDCD1 NudC domain containing 1 Nucleus −0.20 0.02 0.20 0.07
260 NUMA1 nuclear mitotic apparatus protein 1 Nucleus 0.34 0.00 −0.26 0.08
261 NUP188 nucleoporin 188 Nucleus 0.29 0.00 −0.21 0.08
262 OGDH oxoglutarate dehydrogenase Cytoplasm 0.36 0.00 −0.34 0.05
263 OGDHL oxoglutarate dehydrogenase like Other 0.25 0.01 −0.27 0.08
264 OLFM2 olfactomedin 2 Cytoplasm 0.31 0.00 −0.25 0.04
265 OPRM1 opioid receptor mu 1 Plasma Membrane −0.28 0.00 0.23 0.01
266 OSBPL7 oxysterol binding protein like 7 Cytoplasm 0.27 0.00 −0.26 0.03
267 P2RY2 purinergic receptor P2Y2 Plasma Membrane 0.31 0.00 −0.30 0.07
268 PALM paralemmin Plasma Membrane −0.30 0.00 −0.27 0.05
269 PAPLN papilin, proteoglycan like sulfated glycoprotein Extracellular Space 0.20 0.09 −0.34 0.08
270 PC pyruvate carboxylase Cytoplasm 0.21 0.00 −0.30 0.04
271 PCIF1 PDX1 C-terminal inhibiting factor 1 Nucleus 0.25 0.01 −0.34 0.04
272 PCNX2 pecanex 2 Other 0.24 0.01 −0.37 0.04
273 PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor Extracellular Space −0.32 0.10 −0.36 0.05
274 PDE4A phosphodiesterase 4A Cytoplasm 0.32 0.01 −0.39 0.02
275 PDGFRB platelet derived growth factor receptor beta Plasma Membrane 0.54 0.00 −0.27 0.09
276 PDK2 pyruvate dehydrogenase kinase 2 Cytoplasm 0.37 0.00 −0.31 0.10
277 Perm1 PPARGC1 and ESRR induced regulator, muscle 1 Other 0.52 0.01 −0.37 0.08
278 PGP phosphoglycolate phosphatase Cytoplasm −0.35 0.00 −0.29 0.02
279 PHACTR4 phosphatase and actin regulator 4 Plasma Membrane 0.24 0.05 −0.26 0.07
280 PHLDA1 pleckstrin homology like domain family A member 1 Cytoplasm −0.28 0.05 −0.32 0.05
281 PHRF1 PHD and ring finger domains 1 Nucleus 0.28 0.00 −0.32 0.06
282 PHYHIP phytanoyl-CoA 2-hydroxylase interacting protein Cytoplasm 0.34 0.03 −0.45 0.08
283 PIAS3 protein inhibitor of activated STAT 3 Nucleus 0.25 0.00 −0.20 0.04
284 PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic Cytoplasm 0.24 0.00 −0.41 0.01
285 PLA2R1 subunit delta phospholipase A2 receptor 1 Plasma Membrane −0.21 0.04 0.24 0.09
286 PLAGL2 PLAG1 like zinc finger 2 Nucleus 0.43 0.00 −0.31 0.06
287 PLEKHM1 pleckstrin homology and RUN domain containing M1 Cytoplasm 0.29 0.00 −0.26 0.06
288 PLPP3 phospholipid phosphatase 3 Plasma Membrane 0.26 0.00 −0.29 0.05
289 PLRG1 pleiotropic regulator 1 Nucleus −0.21 0.01 0.21 0.07
290 PLTP phospholipid transfer protein Extracellular Space 0.49 0.00 −0.30 0.04
291 PLXNA2 plexin A2 Plasma Membrane 0.25 0.00 −0.28 0.08
292 PLXNB1 plexin B1 Plasma Membrane 0.28 0.02 −0.36 0.02
293 PLXNB3 plexin B3 Plasma Membrane 0.38 0.00 −0.30 0.05
294 PMEPA1 prostate transmembrane protein, androgen induced 1 Plasma Membrane −0.27 0.00 −0.33 0.01
295 POLR2A RNA polymerase II subunit A Nucleus 0.21 0.06 −0.44 0.02
296 POR cytochrome p450 oxidoreductase Cytoplasm 0.41 0.00 −0.33 0.04
297 PPEF1 protein phosphatase with EF-hand domain 1 Extracellular Space −0.22 0.00 0.23 0.02
298 PPP1R10 protein phosphatase 1 regulatory subunit 10 Nucleus 0.26 0.00 −0.58 0.01
299 PPP1R3E protein phosphatase 1 regulatory subunit 3E Cytoplasm −0.28 0.04 −0.30 0.09
300 PPP1R9B protein phosphatase 1 regulatory subunit 9B Cytoplasm −0.34 0.00 −0.26 0.04
301 PRELP proline and arginine rich end leucine rich repeat protein Extracellular Space 0.35 0.00 −0.25 0.07
302 Prrxl1 paired related homeobox protein-like 1 Other 0.24 0.00 −0.29 0.06
303 PRTN3 proteinase 3 Extracellular Space 0.58 0.01 −0.45 0.09
304 PSMA5 proteasome subunit alpha 5 Cytoplasm −0.22 0.00 0.21 0.05
305 PSMB10 proteasome subunit beta 10 Cytoplasm −0.22 0.08 0.29 0.10
306 PSMB3 proteasome subunit beta 3 Cytoplasm −0.22 0.00 0.22 0.03
307 PSMB7 proteasome subunit beta 7 Cytoplasm −0.21 0.00 0.20 0.05
308 PTPRU protein tyrosine phosphatase receptor type U Plasma Membrane 0.37 0.00 −0.32 0.04
309 PXN paxillin Cytoplasm 0.25 0.01 −0.25 0.08
310 RAB4A RAB4A, member RAS oncogene family Cytoplasm 0.24 0.00 −0.25 0.04
311 RASL10B RAS like family 10 member B Other −0.21 0.00 −0.28 0.05
312 RAVER1 ribonucleoprotein, PTB binding 1 Nucleus 0.22 0.03 −0.48 0.01
313 RBM38 RNA binding motif protein 38 Nucleus 0.85 0.00 −0.57 0.02
314 RCC2 regulator of chromosome condensation 2 Nucleus −0.21 0.00 −0.26 0.07
315 RCSD1 RCSD domain containing 1 Other 0.22 0.02 −0.23 0.06
316 REEP4 receptor accessory protein 4 Cytoplasm 0.33 0.01 −0.27 0.06
317 REEP6 receptor accessory protein 6 Plasma Membrane 0.38 0.04 −0.41 0.07
318 RELN reelin Extracellular Space 0.28 0.00 −0.38 0.03
319 Retnlg resistin like gamma Extracellular Space 0.49 0.07 −0.34 0.08
320 RFXANK regulatory factor X associated ankyrin containing protein Nucleus 0.20 0.09 −0.21 0.08
321 RHCE/RHD Rh blood group D antigen Plasma Membrane 1.07 0.02 −0.54 0.05
322 RHOT2 ras homolog family member T2 Cytoplasm 0.20 0.00 −0.21 0.05
323 Rn18s-rs5 18 s RNA, related sequence 5 Other −0.98 0.00 0.79 0.06
324 RNF123 ring finger protein 123 Cytoplasm 0.32 0.00 −0.27 0.09
325 RNF208 ring finger protein 208 Other −0.22 0.02 −0.35 0.02
326 RNF216 ring finger protein 216 Cytoplasm 0.33 0.00 −0.36 0.08
327 RPAP1 RNA polymerase II associated protein 1 Other 0.33 0.00 −0.34 0.03
328 RPH3A rabphilin 3A Plasma Membrane 0.21 0.01 −0.50 0.01
329 Rpl22l1 ribosomal protein L22 like 1 Other −0.27 0.00 0.20 0.06
330 RPL26 ribosomal protein L26 Cytoplasm −0.21 0.00 0.22 0.04
331 RPL37A ribosomal protein L37a Cytoplasm −0.21 0.00 0.22 0.04
332 RPS6KA1 ribosomal protein S6 kinase A1 Cytoplasm 0.32 0.00 −0.42 0.01
333 RRM2 ribonucleotide reductase regulatory subunit M2 Nucleus 0.91 0.00 −0.44 0.03
334 RTN4R reticulon 4 receptor Plasma Membrane −0.22 0.08 −0.26 0.07
335 RXRG retinoid X receptor gamma Nucleus 0.28 0.00 −0.21 0.08
336 SAMD14 sterile alpha motif domain containing 14 Other −0.21 0.01 −0.28 0.03
337 SAP130 Sin3A associated protein 130 Nucleus 0.42 0.00 −0.24 0.09
338 SCG2 secretogranin II Extracellular Space −0.22 0.01 0.20 0.08
339 SCN5A sodium voltage-gated channel alpha subunit 5 Plasma Membrane 0.23 0.05 −0.31 0.05
340 SCRT1 scratch family transcriptional repressor 1 Nucleus −0.23 0.04 −0.41 0.02
341 SCUBE1 signal peptide, CUB domain and EGF like domain containing 1 Plasma Membrane 0.26 0.01 −0.48 0.02
342 SDC3 syndecan 3 Plasma Membrane −0.22 0.00 −0.25 0.07
343 SEC24C SEC24 homolog C, COPII coat complex component Cytoplasm 0.20 0.00 −0.29 0.03
344 SEMA4B semaphorin 4B Plasma Membrane 0.28 0.00 −0.23 0.07
345 SEMA4G semaphorin 4G Plasma Membrane 0.32 0.01 −0.47 0.00
346 SEPTIN8 septin 8 Extracellular Space 0.21 0.00 −0.23 0.05
347 SERPINA3 serpin family A member 3 Extracellular Space −0.30 0.00 0.23 0.01
348 Serpina3g (includes others) serine (or cysteine) peptidase inhibitor, clade A, member 3G Cytoplasm −0.49 0.01 0.22 0.03
349 SERPINB1 serpin family B member 1 Cytoplasm −0.36 0.00 0.21 0.07
350 Serpinb1b serine (or cysteine) peptidase inhibitor, clade B, member 1b Other −0.23 0.01 0.22 0.08
351 SEZ6L seizure related 6 homolog like Plasma Membrane 0.41 0.00 −0.59 0.01
352 SFRP5 secreted frizzled related protein 5 Plasma Membrane −0.21 0.00 −0.30 0.00
353 SH2D3C SH2 domain containing 3C Cytoplasm 0.23 0.00 −0.24 0.10
354 SHMT2 serine hydroxymethyltransferase 2 Cytoplasm 0.23 0.02 −0.27 0.05
355 SIX5 SIX homeobox 5 Nucleus 0.32 0.09 −0.34 0.09
356 SKIV2L Ski2 like RNA helicase Nucleus 0.21 0.00 −0.32 0.03
357 SLC16A10 solute carrier family 16 member 10 Plasma Membrane 0.51 0.03 −0.45 0.05
358 SLC25A37 solute carrier family 25 member 37 Cytoplasm 0.64 0.00 −0.24 0.08
359 SLC40A1 solute carrier family 40 member 1 Plasma Membrane 0.56 0.00 −0.33 0.06
360 SLC4A11 solute carrier family 4 member 11 Plasma Membrane 0.29 0.00 −0.28 0.04
361 SLC7A8 solute carrier family 7 member 8 Plasma Membrane 0.48 0.00 −0.36 0.07
362 SLC9A1 solute carrier family 9 member A1 Plasma Membrane 0.23 0.01 −0.42 0.04
363 SLIT1 slit guidance ligand 1 Extracellular Space 0.24 0.01 −0.36 0.06
364 SLX4 SLX4 structure-specific endonuclease subunit Nucleus 0.39 0.00 −0.24 0.06
365 SMTN smoothelin Extracellular Space 0.49 0.00 −0.37 0.03
366 SNCB synuclein beta Cytoplasm −0.32 0.00 −0.25 0.06
367 SNPH syntaphilin Plasma Membrane 0.22 0.00 −0.31 0.02
368 SOBP sine oculis binding protein homolog Nucleus −0.23 0.01 −0.34 0.02
369 SOD3 superoxide dismutase 3 Extracellular Space 0.41 0.00 −0.49 0.02
370 SOX6 SRY-box transcription factor 6 Nucleus 0.24 0.04 −0.30 0.04
371 Spaca6 sperm acrosome associated 6 Other 0.42 0.02 0.33 0.04
372 SPECC1 sperm antigen with calponin homology and coiled-coil domains 1 Nucleus 0.22 0.05 −0.26 0.07
373 SPIRE2 spire type actin nucleation factor 2 Cytoplasm −0.31 0.00 −0.27 0.02
374 SPSB3 splA/ryanodine receptor domain and SOCS box containing 3 Cytoplasm 0.23 0.06 −0.34 0.03
375 SPTBN5 spectrin beta, non-erythrocytic 5 Plasma Membrane 0.32 0.01 −0.36 0.05
376 SRCAP Snf2 related CREBBP activator protein Cytoplasm 0.20 0.10 −0.31 0.02
377 ST5 suppression of tumorigenicity 5 Cytoplasm 0.26 0.00 −0.25 0.09
378 STK10 serine/threonine kinase 10 Cytoplasm 0.21 0.03 −0.36 0.00
379 STUB1 STIP1 homology and U-box containing protein 1 Cytoplasm 0.24 0.00 −0.23 0.05
380 SUGP1 SURP and G-patch domain containing 1 Nucleus 0.32 0.00 −0.21 0.06
381 SYT2 synaptotagmin 2 Cytoplasm 0.24 0.01 −0.43 0.03
382 TAFA5 TAFA chemokine like family member 5 Extracellular Space −0.25 0.00 −0.24 0.05
383 TBC1D17 TBC1 domain family member 17 Cytoplasm 0.24 0.00 −0.29 0.08
384 TCOF1 treacle ribosome biogenesis factor 1 Nucleus 0.23 0.07 −0.43 0.05
385 TECPR2 tectonin beta-propeller repeat containing 2 Other 0.20 0.01 −0.25 0.08
386 TENM2 teneurin transmembrane protein 2 Plasma Membrane 0.42 0.00 −0.28 0.08
387 TENM3 teneurin transmembrane protein 3 Plasma Membrane 0.26 0.00 −0.34 0.05
388 TENM4 teneurin transmembrane protein 4 Plasma Membrane 0.20 0.06 −0.46 0.02
389 TGFB1I1 transforming growth factor beta 1 induced transcript 1 Nucleus 0.35 0.00 −0.36 0.01
390 THBS1 thrombospondin 1 Extracellular Space 0.68 0.00 −0.24 0.02
391 THEM6 thioesterase superfamily member 6 Other −0.23 0.00 −0.32 0.02
392 TIAM1 T cell lymphoma invasion and metastasis 1 Cytoplasm 0.30 0.00 −0.44 0.01
393 TINAGL1 tubulointerstitial nephritis antigen like 1 Extracellular Space 0.28 0.01 −0.35 0.03
394 TLN1 talin 1 Plasma Membrane 0.39 0.00 −0.39 0.05
395 TMEM151B transmembrane protein 151B Other −0.30 0.00 −0.27 0.07
396 TMEM160 transmembrane protein 160 Cytoplasm −0.25 0.02 0.24 0.07
397 TMEM205 transmembrane protein 205 Cytoplasm −0.26 0.00 0.23 0.08
398 TNFAIP2 TNF alpha induced protein 2 Extracellular Space 0.53 0.00 −0.42 0.06
399 TNFRSF1A TNF receptor superfamily member 1A Plasma Membrane 0.23 0.01 −0.29 0.08
400 TNIP1 TNFAIP3 interacting protein 1 Nucleus 0.21 0.02 −0.38 0.01
401 TNXB tenascin XB Extracellular Space 0.26 0.01 −0.27 0.02
402 TOM1L2 target of myb1 like 2 membrane trafficking protein Cytoplasm 0.21 0.00 −0.29 0.05
403 TONSL tonsoku like, DNA repair protein Cytoplasm 0.43 0.00 −0.38 0.05
404 TPRA1 transmembrane protein adipocyte associated 1 Plasma Membrane 0.28 0.00 −0.30 0.00
405 TPRN taperin Extracellular Space −0.28 0.02 −0.26 0.08
406 TRPA1 transient receptor potential cation channel subfamily A member 1 Plasma Membrane −0.31 0.00 0.29 0.02
407 TRPC6 transient receptor potential cation channel subfamily C member 6 Plasma Membrane −0.20 0.04 0.29 0.01
408 TRPM2 transient receptor potential cation channel subfamily M member 2 Plasma Membrane 0.26 0.00 −0.23 0.05
409 TRRAP transformation/transcription domain associated protein Nucleus 0.37 0.00 −0.25 0.05
410 TSPAN18 tetraspanin 18 Other 0.25 0.00 −0.27 0.08
411 TSPAN33 tetraspanin 33 Plasma Membrane 0.46 0.02 −0.35 0.07
412 TTBK1 tau tubulin kinase 1 Other −0.26 0.00 −0.40 0.02
413 TTC9B tetratricopeptide repeat domain 9B Other −0.38 0.00 −0.24 0.09
414 TTLL3 tubulin tyrosine ligase like 3 Extracellular Space 0.61 0.00 −0.36 0.04
415 TTYH3 tweety family member 3 Plasma Membrane −0.21 0.02 −0.23 0.09
416 UBC ubiquitin C Cytoplasm 0.58 0.00 −0.40 0.05
417 UBE3B ubiquitin protein ligase E3B Extracellular Space 0.31 0.00 −0.38 0.05
418 UBL7 ubiquitin like 7 Other 0.22 0.02 −0.25 0.10
419 UFSP2 UFM1 specific peptidase 2 Other −0.22 0.00 0.20 0.06
420 ULK3 unc-51 like kinase 3 Cytoplasm 0.27 0.00 −0.22 0.05
421 UNC5A unc-5 netrin receptor A Plasma Membrane −0.27 0.05 −0.33 0.07
422 USP10 ubiquitin specific peptidase 10 Cytoplasm 0.31 0.00 −0.30 0.08
423 USP19 ubiquitin specific peptidase 19 Cytoplasm 0.20 0.01 −0.24 0.06
424 VGF VGF nerve growth factor inducible Extracellular Space −0.73 0.00 −0.35 0.07
425 VPS18 VPS18 core subunit of CORVET and HOPS complexes Cytoplasm 0.22 0.02 −0.35 0.05
426 VPS9D1 VPS9 domain containing 1 Other 0.22 0.01 −0.29 0.05
427 VWA5A von Willebrand factor A domain containing 5A Nucleus −0.28 0.00 0.24 0.02
428 WASF1 WASP family member 1 Nucleus −0.27 0.02 −0.29 0.06
429 WBP2 WW domain binding protein 2 Cytoplasm 0.28 0.00 −0.36 0.04
430 WDFY3 WD repeat and FYVE domain containing 3 Cytoplasm 0.22 0.01 −0.37 0.03
431 YLPM1 YLP motif containing 1 Nucleus 0.25 0.00 −0.24 0.02
432 ZDHHC18 zinc finger DHHC-type containing 18 Cytoplasm −0.23 0.01 −0.29 0.05
433 ZFP36L1 ZFP36 ring finger protein like 1 Nucleus 0.23 0.03 −0.25 0.10
434 Zfp651 zinc finger protein 651 Other −0.23 0.00 −0.21 0.03
435 ZFYVE26 zinc finger FYVE-type containing 26 Cytoplasm 0.44 0.00 −0.28 0.05
436 ZNF142 zinc finger protein 142 Nucleus 0.30 0.00 −0.23 0.09
437 ZNF219 zinc finger protein 219 Nucleus −0.21 0.01 −0.28 0.02
438 ZNF423 zinc finger protein 423 Nucleus 0.26 0.01 −0.46 0.01
439 ZNF442 zinc finger protein 442 Nucleus −0.22 0.05 0.35 0.09
440 ZNF592 zinc finger protein 592 Nucleus 0.27 0.01 −0.29 0.05
441 ZNF646 zinc finger protein 646 Nucleus 0.26 0.00 −0.26 0.04
442 ZNF703 zinc finger protein 703 Nucleus −0.30 0.00 −0.27 0.07
443 ZSWIM1 zinc finger SWIM-type containing 1 Nucleus 0.35 0.00 −0.40 0.05