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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Biochem Pharmacol. 2021 Jul 16;192:114688. doi: 10.1016/j.bcp.2021.114688

Table 2.

Top five upstream regulators and their mechanistic network for differentially expressed.

Upstream Regulator Activation z-score Overlap p-value Mechanistic Network Other Regulators in mechanistic network
1 HTT −0.152 1.3E-10
2 APP 2.394 1.67E-10 431 (8) TP53, NOTCH1, SP1, TP73, HIF1A, MYC, STAT3
3 TP53 −2.078 1.77E-10 481 (14) STAT3, ERBB2, TP73, HIF1A,SP1, ESTROGEN RECEPTOR, NOTCH1, CTNNB1, CREBBP, SMAD4, SMAD3, FOS, STAT1
4 TGFB1 −5.111 2.84E-09 436 (13) EGFP, ERBB2, NOTCH1, SP1, STAT3, EGR1, SMAD4, CREBBP, SMAD3, ESTROGEN RECEPTOR, CTNNB1, AR
5 estrogen receptor −0.614 6.22E-09 558 (15) TP53, BETA-ESTRADIOL, AR, CREBBP, ESR2, ESR1, SP1, TP73, HIF1A, STAT3, NOTCH1, DIETHYLSTILBESTEROL,4-HYDROXYTAMOXIFEN, ESTROGEN

genes in cisplatin dataset (cisplatin vs. cisplatin + TTI-101). Note, the number in the mechanistic network column denotes the number of target genes influenced by that particular regulator. The number in parenthesis denotes the total number of regulators in that mechanistic network.