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. Author manuscript; available in PMC: 2022 Oct 1.
Published in final edited form as: Neuropharmacology. 2021 Jul 31;197:108739. doi: 10.1016/j.neuropharm.2021.108739

Figure 2 -. EpiP significantly lowers ISO concentration necessary to induce hypnosis and lowers ISO and SEVO anesthetic concentration in WT mice.

Figure 2 -

A. A low dose of EpiP yielded a significant decrease in concentration of ISO necessary to induce LORR (unpaired two-tailed t-test t(13) = 5.20, p < 0.001). Animals given a sub-hypnotic dose of 25 mg/kg i.p injection of EpiP required 0.295 atm (95% CI +/− 0.058) less ISO than animals given vehicle alone to cause LORR. B. EpiP lowered the anesthetic concentration of ISO necessary to immobilize WT mice and inhibit the LOWR in a dose-dependent manner - left (one way ANOVA F(2,22) = 82.43, p < 0.001, post hoc presented on Figure). At 25 mg/kg of EpiP lowered ISO requirements for LOWR by 0.185 atm. At the dose of 50 mg/kg, EpiP further lowered the ISO requirement by 0.462 atm. Similarly EpiP lowered the anesthetic concentration of SEVO necessary to immobilize WT mice and inhibit the LOWR in a dose-dependent manner - right (one way ANOVA F(2,12) = 22.00, p < 0.001, post hoc presented on Figure).