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. Author manuscript; available in PMC: 2022 Oct 1.
Published in final edited form as: Neuropharmacology. 2021 Jul 31;197:108739. doi: 10.1016/j.neuropharm.2021.108739

Figure 3. Time course of total EEG power change after vehicle or EpiP injections.

Figure 3.

Total δ (A), θ (B), α (C), β (D) and γ (E) power during baseline recordings and 60 min after vehicle or neurosteroid i.p. injection (in 5-min bins). A. EpiP-injected animals had more absolute power in δ frequency range (0.5–4 Hz) in comparison to control (vehicle) (two way RM ANOVA, Interaction F(11,110) = 0.592, p = 0.832; EpiP F(1,10) = 26.47, p < 0.001, Time F(11,110) = 2.459, p = 0.009). B. EpiP-injected animals had more absolute power in θ frequency range (4–8 Hz) (two way RM ANOVA, Interaction F(11,110) = 0.621, p = 0.808; EpiP F(1,10) = 38.57, p < 0.001, Time F(11,110) = 1.413, p = 0.177). C. EpiP-injected animals had more absolute power in α frequency range (8–13 Hz) (two way RM ANOVA, Interaction F(11,110) = 1.130, p = 0.345; EpiP F(1,10) = 21.54, p < 0.001, Time F(11,110) = 1.492, p = 0.145). Note that baseline power in α frequency range was higher during baseline in EpiP experiment (paired t-test t(10) = 5.989, p < 0.001). D. EpiP-injected animals had more absolute power in β frequency range (13–30 Hz) (two way RM ANOVA, Interaction F(11,110) = 1.113, p = 0.358; EpiP F(1,10) = 31.48, p < 0.001, Time F(11,110) = 0.984, p = 0.465). Note that baseline power in β frequency range was higher during baseline in EpiP experiment (paired t-test t(10) = 2.326, p = 0.042). E. EpiP-injected animals had more absolute power in γ frequency range (30–50 Hz) in comparison to control (two way RM ANOVA, Interaction F(11,110) = 8.414, p < 0.001; EpiP F(1,10) = 14.05, p = 0.004, Time F(11,110) = 5.716, p < 0.001, post hoc presented on Figure). Analysis of recordings from 11 animals, the same animals were injected with vehicle on Day 1 and 24 hours later (Day 2) they were injected with EpiP 100 mg/kg.