Table 5.

Differentially abundant osteoclast proteins identified using Cten.

Symbol	Name	Female DKO	Male DKO
s100a8*	Protein S100-A8	0.13	0.18
S100a9$	Protein S100-A9	0.17	0.17
CAMP	Cathelicidin antimicrobial peptide	0.21	0.42
Ltf	Lactotransferrin	0.22	0.21
Ctsk*	Cathepsin K	0.24	0.39
Ppbp#	Chemokine (C-X-C motif) ligand 7, isoform CRA_b	0.24	0.52
Itgam	Integrin αM	0.26	0.39
Ngp	Neutrophilic granule protein	0.28	0.30
Itgb2*	Integrin beta-2	0.28	0.39
Rac2	Ras-related C3 botulinum toxin substrate 2	0.28	0.38
Acp5#	Tartrate-resistant acid phosphatase type 5	0.29	0.33
Icn2	Neutrophil gelatinase-associated lipocalin	0.29	0.31
msn	moesin	0.29	0.53
Sash3*	SAM and SH3 domain-containing protein 3	0.30	0.41
Cybb	Cytochrome B 245-β-chain	0.30	0.42
Lyz2*	Lysozyme C-2	0.31	0.31
Mmp8	Neutrophil collagenase	0.34	0.38
Aldh3b1	Aldehyde dehydrogenase family 3 member B1	0.34	0.51
FCGR2B	Fc fragment of IgG receptor IIb	0.34	0.45
Ncf2*	Neutrophil cytosol factor 2	0.34	0.36
MMP9	Matrix Metalloproteinase 9	0.35	0.33
Ncf1	Neutrophil cytosol factor 1	0.35	0.38
Emb	Embigen	0.36	0.53
Hk3	Hexokinase-3	0.37	0.37
Ptpn6#	Isoform 2 of Tyrosine-protein phosphatase non-receptor type 6	0.37	0.40
lcp1#	Plastin-2	0.38	0.40
Grn	Granulins	0.39	0.50
Fermt3	Fermitin family homolog 3	0.41	0.53
Fgr	Tyrosine-protein kinase Fgr	0.42	0.40
Cfp#	Properdin	0.44	0.47
Prtn3*	Myeloblastin	0.46	0.50
Lgals3*	Galectin-3-binding protein	0.48	0.50
Spn	Leukosialin	0.50	0.42
Tcirg1#	V-type proton ATPase subunit a	0.51	0.49
Tpd52*	Tumor protein D52	0.51	0.42
Hcls1	Hematopoietic lineage cell-specific protein	0.54	0.44

All proteins in Table 5 are highly expressed cell specific (HECS) osteoclast genes in CTen and all except S100A9 ($) are also listed in a published RNAseq data set obtained from osteocytes undergoing in vitro maturation.

^*Denotes gene that increases during in vitro osteocyte maturation and is also listed in table Table S2.

^#Denotes gene that decreases during in vitro osteocyte maturation and is also listed in table S3.