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. 2021 Sep 28;12:5690. doi: 10.1038/s41467-021-25998-2

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© The Author(s) 2021, corrected publication 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Side view of a three-dimensional (3D) reconstruction of NDCBE with individually colored monomers. b Cartoon representation of NDCBE dimer. TMs 1-14 and helices H1-10 are shown as cylinders. c Topology and domain arrangement of the NDCBE monomer. Four highly conserved cysteines are labeled as red dot. The branched structures at Asn646 and Asn666 represent N-linked glycosylation. d Structure of NDCBE monomer in side (left) and extracellular (right) views. e Interactions contributing to EL3 assembly. f EL3 and TMD components involved in formation of the dimeric interface. g Cryo-EM densities showing the disulfide bond between Cys636 and Cys684 (left) and two N-glycosylation sites at Asn646 and Asn666 (right); the map was low-pass filtered to 5 Å for the two N-glycosylation sites.