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. 2021 Sep 28;12(10):886. doi: 10.1038/s41419-021-04170-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A The heatmap of DEGs, as detected by RNA-seq in human articular chondrocytes treated with either SR3335 (1 µM) or vehicle (DMSO) for 48 h (n = 3 biological replicates). B KEGG and C GO terms with the most significant P values. BP biological process, CC cellular component, MF molecular function. D GSEA of positively associated GO terms with SR3335 treatment (left panel) and cholesterol metabolic hallmark genes in chondrocytes treated with RORα antagonist compared with vehicle (middle and right panel). E GSEA of negatively associated GO terms with SR3335 treatment (left panel) and IL-6-associated genes in chondrocytes treated with SR3335 compared with vehicle (middle and right panel).