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. 2021 Sep 28;12(10):886. doi: 10.1038/s41419-021-04170-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — RORα directly interacts with STAT3 protein or the promoter region of IL6 gene, thereby accelerating the cartilage depredating effect of inflammatory cytokine. RORα blockade with either SR3335 or small interfering RNA resulted in the decreased level of STAT3 phosphorylation, and subsequently restored the expression of aggrecan, collagen type II, MMP, and ADAMTS. Finally, RORα blockade ameliorated the progression of cartilage damage.