Table 2.
Mean pancreatic enzyme levels at baseline and Week 26 in Chinese patients with T2DM receiving dulaglutide 1.5 mg, stratified by potential influencing factors
| Subgroup | n | Pancreatic amylase, U/L | Total amylase, U/L | Lipase, U/L | |||
|---|---|---|---|---|---|---|---|
| BL | W26 | BL | W26 | BL | W26 | ||
| Age | |||||||
| < 60 years | 143 | 24.06 | 30.18 | 54.78 | 62.46 | 38.31 | 51.42 |
| ≥ 60 years | 60 | 28.23 | 34.23 | 62.18 | 69.40 | 43.63 | 52.77 |
| Sex | |||||||
| Male | 120 | 25.63 | 31.77 | 57.35 | 64.66 | 40.18 | 52.42 |
| Female | 83 | 24.81 | 30.78 | 56.42 | 64.19 | 39.46 | 51.00 |
| Duration of diabetes | |||||||
| < 10 years | 145 | 23.99 | 30.82 | 55.01 | 63.51 | 37.71 | 51.72 |
| ≥ 10 years | 58 | 28.55 | 32.53 | 61.86 | 66.56 | 45.31 | 52.00 |
| Baseline weight | |||||||
| < 70 kg | 89 | 24.74 | 31.22 | 58.42 | 65.85 | 39.67 | 52.20 |
| ≥ 70 kg | 114 | 25.73 | 31.45 | 55.84 | 63.33 | 40.04 | 51.50 |
| Body mass index | |||||||
| < 25 kg/m2 | 88 | 24.93 | 31.17 | 57.11 | 65.60 | 39.57 | 49.74 |
| ≥ 25 kg/m2 | 115 | 25.57 | 31.48 | 56.86 | 63.61 | 40.12 | 53.33 |
| Baseline HbA1c | |||||||
| < 8.5% | 123 | 26.21 | 32.83 | 58.02 | 66.63 | 40.27 | 54.86 |
| ≥ 8.5% | 80 | 23.89 | 29.04 | 55.36 | 61.07 | 39.29 | 47.07 |
| Baseline triglycerides | |||||||
| < 2.3 mmol/L | 149 | 26.38 | 31.40 | 57.54 | 64.18 | 41.01 | 51.04 |
| ≥ 2.3 mmol/L | 54 | 22.31 | 31.19 | 55.41 | 65.25 | 36.78 | 53.98 |
| Concomitant OAMs | |||||||
| Metformin only | 87 | 24.70 | 31.10 | 54.91 | 63.05 | 39.59 | 51.23 |
| SU only | 30 | 25.10 | 30.71 | 56.47 | 63.92 | 39.83 | 49.29 |
| Metformin + SU | 86 | 25.97 | 31.76 | 59.23 | 65.92 | 40.20 | 53.07 |
BL baseline, HbA1c glycated hemoglobin, OAM oral antihyperglycemic medication, SU sulfonylurea, W26 Week 26