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. 2021 Sep 28;12:5618. doi: 10.1038/s41467-021-25583-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Scatterplots showing the estimates (methylation beta-value difference between MZ twins and controls; a positive difference corresponds to a higher methylation level in MZ twins) in the discovery and replication cohorts for MZ-DMPs identified in NTR. The x axis shows the estimates in the discovery EWAS in the Netherlands Twin Register (NTR, N = 1957, whole blood). The y-axis shows the estimates in a The Environmental Risk Longitudinal Twin Study (E-Risk, N = 1164, whole blood). b The Finnish Twin Cohort (FTC, N = 1708, whole blood). c The UK Adult Twin Registry (TwinsUK, N = 492, whole blood). In TwinsUK, residuals obtained after correcting for covariates were analyzed instead of methylation beta values. d The Brisbane Systems Genetic Study (BSGS, N = 356, whole blood). e An independent child data set from the NTR (N = 765, buccal). Each dot is one methylation site. Methylation sites that replicate following stringent Bonferroni correction for 243 tests and after correction for inflation of genome-wide test statistics, where applicable, are displayed in dark purple, all other sites are shown in green. r = correlation.