Table 1.
Cohort descriptives.
| Cohort | N total EWAS | N MZ twins | N DZ twins | N family membersa | % female | Age, mean (SD) | Tissue | Array |
|---|---|---|---|---|---|---|---|---|
| NTR | 1957 | 924 | 1033 | 237a | 65.3 | 34.9 (11.3) | Blood | 450k |
| E-Risk | 1164 | 470 | 694 | – | 48.9 | 18 (0.4) | Blood | 450k |
| FTC | 1708 | 559 | 1149 | – | 63.7 | 38.6 (20.2) | Blood | 450k/EPIC |
| TwinsUK | 492 | 395 | 97 | – | 100 | 58 (10.1) | Blood | 450k |
| BSGS | 356 | 134 | 222 | 257a | 48.9 | 21.4 (14.1) | Blood | 450k |
| NTR | 765 | 564 | 201 | – | 48.8 | 9.6 (1.8) | Buccal | EPIC |
N number of persons (numbers refer to twin individuals, not twin pairs).
aFamily members of twins (siblings and parents) were not included in the primary EWAS meta-analysis; they were included in sensitivity analyses, and in penalized regression model analyses. Netherlands Twin Register (NTR), Environmental Risk Longitudinal Twin Study (E-Risk); Finnish Twin Cohort (FTC); UK Adult Twin Registry (TwinsUK); Brisbane Systems Genetic Study (BSGS).