Fig. 8. The effect of pre-existing resistant mutants for different magnitudes of collateral sensitivity on the probability of resistance (PoR).
PoR was estimated at the end of treatment for different scenarios of low levels of pre-existing resistance (columns) and antibiotic types (rows). Subpopulation-specific probability of resistance is indicated by colour and PoR of RAny, defined as the presence of any resistant subpopulation, is indicated in grey. Each simulated scenario was realized n = 500 times. Data are presented as mean PoR with the error bars that represent the standard error of the estimation. A, D, G, J No pre-existing resistance. B, E, H, K Low levels of pre-existing resistance towards the second drug (DB). C, F, I, L Low levels of pre-existing resistance forwards the first drug (DA).