Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Sep 28;12:5680. doi: 10.1038/s41467-021-25917-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 2 — a A visual representation of the relevant parameters of the blood exchange technique to solve for the generation rate and the half-life time of CTCs. The circulatory system of each mouse is represented as a well-mixed container of red spheres (CTCs). In the TBM (left tank) CTCs enter the circulation from the tumor microenvironment at a rate equal to r_gen. CTC clearance out of the circulation is represented by a hole at the bottom of each container with a clearance rate of K_clear × N. Pumps with counters represent the CTC counter systems and their peristaltic pumps that transfer the CTC-containing blood at rates equal to C × Q. r: rate of CTC transfer. C: concentration. Q: flow rate. K_clear: first-order clearance coefficient. N: total number of CTCs in each mouse. b Scatter plots for the calculated CTC generation rates and the half-life times of each of the different small-cell lung cancer (SCLC), pancreatic ductal adenocarcinoma (PDAC), and non-small-cell lung cancer (NSCLC) blood-exchange experiments (*p < 0.05 (p = 0.0136), Kruskal−Wallis nonparametric test with Dunn’s sample pairs analysis). For SCLC, n = 5 biologically independent experiments. For PDAC, n = 8, 5, and 1 biologically independent experiments, respectively, for Org, Org. Neo., and Auto. For NSCLC, n = 5 biologically independent experiments. Auto autochthonous. Org. organoid. Neo neoantigen. ns not significant.