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. 2021 Sep 15;9:711787. doi: 10.3389/fbioe.2021.711787

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Copyright © 2021 Wang, Dong, Wei, Wang, Chang, Wu, Liu, Chang, Yin, Luo, Jia, Yan and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) SEM images of GA porous-lipid/PLGA MBs. (B) TEM images of GA porous-lipid/PLGA MBs. (C) Size of GA porous-lipid/PLGA MBs. (D) Zeta potential of GA porous-lipid/PLGA MBs. (E) Drug loading of GA porous-lipid /PLGA MBs. Compared with other groups, the drug-loading rate corresponding to the 4 mg of GA plus 50 mg of PLGA is 7.65 ± 0.15% (*p < 0.05 versus other three groups). (F) Encapsulation efficiency of GA porous-lipid/PLGA MBs. Compared with other groups, the encapsulation efficiency corresponding to the 4 mg of GA plus 50 mg PLGA is 95.57 ± 1.89% (*p < 0.05 versus other three groups). (G) The particle size and concentration of GA porous-lipid/PLGA MBs were measured at the 0th, 1st, 2nd, 4th, 6th, and 8th day. The concentration of GA porous-lipid/PLGA MBs is expressed by OD₅₀₀. (H) The particle size distribution of GA porous-lipid/PLGA MBs on the 0th, 1st, 2nd, 4th, 6th, and 8th day.