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. 2021 Sep 15;9:711787. doi: 10.3389/fbioe.2021.711787

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Copyright © 2021 Wang, Dong, Wei, Wang, Chang, Wu, Liu, Chang, Yin, Luo, Jia, Yan and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) The in vitro BBB model. Blue indicates the nucleus and green indicates the ZO-1 tight junction protein. (B) Resistance change of the in vitro BBB model. The resistance value of the BBB model was 105.12 ± 4.92 Ω.CM² on the fifth day (**p < 0.01 versus the other group). (C) L (Alexa Fluor488) fluorescent secondary antibody labeled the ZO-1 tight junction protein. DAPI labeled the nucleus. FUS combined with lipid MBs or GA/PLGA MBs could open the BBB model, and the white arrow indicates that the tight junction part was already open. (D) Florescent intensity of NaF in the FUS + MBs group was 1.19 ± 0.02 (***p < 0.001 versus the control group). Florescent intensity of NaF in the FUS + GA/PLGA group was 1.19 ± 0.02 (***p < 0.001 versus the control group and ^# p < 0.05 versus the FUS + MBs group).