Table 1.
Clinical and pathological characteristics of the 189 patients with penile SCC.
| Characteristics | Overall | ILNM only | ILNM and PLNM | p value |
|---|---|---|---|---|
| Number of patients | 189 | 136 | 53 | – |
| Age, Median (IQR) | 52 (44–62) | 51 (43-59) | 55 (47-67) | 0.423^ |
| Treatment of primary tumor, n (%) | 0.714* | |||
| Circumcision | 16 (8.5%) | 10 (7.4%) | 6 (11.3%) | |
| Partial penectomy | 137 (72.5%) | 100 (73.5%) | 37 (69.8%) | |
| Total penectomy | 25 (13.2%) | 19 (14.0%) | 6 (11.3%) | |
| Unknow | 11 (5.8%) | 7 (5.1%) | 4 (7.5%) | |
| pT stage, n (%) | 0.428* | |||
| ≤pT1 | 79 (41.8%) | 62 (45.6%) | 17 (32.1%) | |
| pT2 | 56 (29.6%) | 37 (27.2%) | 19 (35.8%) | |
| pT3 | 39 (20.6%) | 26 (19.1%) | 13 (24.5%) | |
| pT4 | 5 (2.6%) | 3 (2.2%) | 2 (3.8%) | |
| pTx | 10 (5.3%) | 8 (5.9%) | 2 (3.8%) | |
| Tumor grade, n (%) | 0.229* | |||
| G1 | 73 (38.6%) | 58 (42.6%) | 15 (28.3%) | |
| G2 | 88 (46.6%) | 61 (44.9%) | 27 (50.9%) | |
| ≥G3 | 19 (10.1%) | 11 (8.1%) | 8 (15.1%) | |
| Gx | 9 (4.8%) | 6 (4.4%) | 3 (5.7%) | |
| No. of ILNs removed, Median (IQR) | 24 (17-29) | 24 (18-30) | 20 (16-27) | 0.058^ |
| No. of deep ILNs removed, Median (IQR) | 3 (2-4) | 3 (2-4) | 3 (2-4) | 0.641^ |
| No. of PLNs removed, Median (IQR) | 20 (14-28) | 20 (14-30) | 21 (14-27) | 0.827^ |
| No. of positive ILNs, Median (IQR) | 2 (1-4) | 2 (1-3) | 4 (2-6) | <0.001^ |
| Deep ILNs, n (%) | <0.001* | |||
| Positive | 33 (17.5%) | 8 (5.9%) | 25 (47.2%) | |
| Negative | 156 (82.5%) | 128 (94.1%) | 28 (52.8%) | |
| Extranodal extension of ILNs, n (%) | 0.001* | |||
| Present | 74 (39.2%) | 43 (31.6%) | 31 (58.5%) | |
| Absent | 115 (60.8%) | 93 (68.4%) | 22 (41.5%) | |
| Diameter of ILN, n (%) | 0.101* | |||
| <30 mm | 88 (46.6%) | 68 (50.0%) | 20 (37.7%) | |
| ≥30 mm | 92 (48.7%) | 60 (44.1%) | 32 (60.4%) | |
| Unknow | 9 (4.8%) | 8 (5.9%) | 1 (1.9%) | |
| Side involvement of ILNs, n (%) | 0.002* | |||
| Bilateral | 80 (42.3%) | 48 (35.3%) | 32 (60.4%) | |
| Unilateral | 109 (57.7%) | 88 (64.7%) | 21 (40.6%) | |
| Lymphovascular invasion, n (%) | 0.087* | |||
| Present | 66 (34.9%) | 41 (30.1%) | 25 (47.2%) | |
| Absent | 118 (62.4%) | 91 (66.9%) | 27 (50.9%) | |
| Unknow | 5 (2.6%) | 4 (2.9%) | 1 (1.9%) | |
| Adjuvant therapy, n (%) | 0.01* | |||
| Positive | 98 (51.9%) | 62 (45.6%) | 32 (61.4%) | |
| Negative | 75 (39.7%) | 66 (48.5%) | 13 (24.5%) | |
| Unknow | 16 (8.5%) | 8 (5.9%) | 8 (15.1%) |
SCC, squamous cell carcinoma; IQR, interquartile range; ILN, inguinal lymph nodes; ILNM, inguinal lymph node metastases; PLN, pelvic lymph nodes; PLNM, pelvic lymph node metastases.
*Chi-square test; ^Mann-Whitney’s test.