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. 2021 Sep 15;12:713090. doi: 10.3389/fphar.2021.713090

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Copyright © 2021 Okagu, Ndefo, Aham and Udenigwe.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Proposed mechanism of anticancer activities of natural products from Zanthoxylum species. CAT, catalase; GPx, glutathione peroxidase; COX-2, cyclooxygenase-2; VEGFR-2, vascular endothelial growth factor receptor-2; CDK1, cyclin-dependent kinase-1; ROS, reactive oxygen species; Bax, Bcl-2-associated X protein; APAF-1, apoptosis protein activating factor-1.