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. 2021 Sep 28;12:5679. doi: 10.1038/s41467-021-25862-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Schematic depiction of Chr.3 with a zoom-in on the EVI1 locus, indicating the exact breakpoints (detected by 3q-seq) of 3q26-rearranged AMLs as vertical lines. In the lowest zoom-in panel the EVI1 promoter with a CTCF binding site upstream marked, respectively by H3K27ac (t(3;8) AML-17, orange) and CTCF (K562 t(3;8) clone 24-7, blue) ChIP-seq. b Schematic overview of Chr.6 and the locus where the breakpoints (black lines) were found by 3q-seq in t(3;6)(q26;q25) AML. The black box indicates the area of which the zoom-in is shown below. Zoom-in: putative enhancer indicated by H3K27ac (t(3;8) AML-17, orange), CTCF binding (K562 t(3;8) clone 24-7, blue) and HSPC active transcription factor recruitment (CD43+ cell²⁹, purple) at translocation site. The lines below indicate the exact breakpoints. The gray bar the minimal translocated region brought into close proximity of EVI1 in that specific translocation. c Same as b, but here for t(3;7)(q26;q11) AMLs. d Same as b, but here for inv(3)/t(3;3)(q21;q26) AMLs. The exact translocated locus was previously shown to be an enhancer of GATA2¹⁵.