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. 2021 Sep 28;11:19184. doi: 10.1038/s41598-021-98718-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Experimental design of the study. Schematic representation of the experimental study. Half of the C57BL/6J mice were fed with an adenine diet 0.25% for 4 weeks to induce chronic kidney disease (CKD). After 2 weeks of washout, mice were divided into 6 subgroups to receive either a low protein diet, a low aromatic amino-acid diet or a normoproteic diet until terminal sacrifice after 6 weeks of specific diet.