Table 1.
Univariate and multivariate Cox regression analyses in each patient set.
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | p-value | HR (95% CI) | p-value | |
| Training set | ||||
| Age | 0.98 (0.95,1.01) | 0.14 | ||
| Gender | 1.01 (0.48,2.14) | 0.98 | ||
| Grade | 0.81 (0.50,1.32) | 0.40 | ||
| Stage | 1.55 (1.06,6.26) | 0.02 | ||
| T | 1.49 (1.04,2.14) | 0.03 | ||
| M | 6.66 (1.55,28.58) | 0.01 | ||
| N | 2.42 (0.33,17.90) | 0.390 | ||
| riskScore | 1.52 (1.30,1.78) | 9.84E−08 | 1.61 (1.33,1.95) | 1.16E−06 |
| Testing set | ||||
| Age | 1.01 (0.99,1.04) | 0.35 | ||
| Gender | 0.59 (0.31,1.14) | 0.12 | ||
| Grade | 1.20 (0.78,1.86) | 0.40 | ||
| Stage | 2.66 (1.83,3.88) | 3.46E−07 | ||
| T | 2.50 (1.79,3.50) | 9.42E−08 | ||
| M | 2.25 (0.31,16.59) | 0.43 | ||
| N | 1.37 (0.19,10.04) | 0.76 | ||
| riskScore | 1.36 (1.22,1.51) | 4.51E−08 | 1.28 (1.14,1.45) | 6.06E−05 |
| External validation set | ||||
| Age | 0.75 (0.29,1.93) | 0.55 | ||
| Gender | 1.07 (0.86,4.92) | 0.07 | ||
| Stage | 1.67 (1.15,4.25) | 0.03 | 3.02 (1.02,8.90) | 0.04 |
| riskScore | 4.51 (2.13,6.37) | 0 | 5.53 (4.13,6.37) | 0 |