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. 2021 Sep 15;11:727306. doi: 10.3389/fonc.2021.727306

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Copyright © 2021 Mu, Zhu, Dong, Shi, Deng and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CALM2 overexpression activated JAK2/STAT3/HIF-1/VEGFA profile in GC tissues and cells. (A) String (https://string-db.org/) was taken for analyzing the potential pathway regulated by CALM2. (B). JAK2/STAT3/HIF-1/VEGFA was discovered to be an underlying downstream pathway of CALM2. (C) IHC ascertained the protein profiles of p-JAK2, p-STAT3, and HIF-1A in the mice’s tumor tissues. (C) Western Blot confirmed the protein profile of the JAK2/STAT3/HIF-1/VEGFA signaling axis in AGS and MKN45 cells with CALM2 overexpression or down-regulation. Data were exhibited as mean ± SD (n=3). **P < 0.01, ***P < 0.001 (vs. the Vector or Si-NC group).