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. 2021 Sep 15;11:695006. doi: 10.3389/fonc.2021.695006

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Copyright © 2021 Yang, Deng, Cheng, Wei, Luo and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Signature score and patients survival outcomes. Patients treated with immune checkpoint inhibitors were divided into high and low signature score groups. Kaplan–Meier curves showed that high score group patients had better survival outcomes: (A) In the pretreatment Gide dataset, p=0.013 (log-rank test) in overall survival, (B) p=0.0002 in progression-free survival. (C) In the on-treatment Gide dataset, p=0.017 for overall survival, (D) p=0.0034 in progression-free survival. (E) In the Mariathasan dataset, p=0.0087 for overall survival. (F) In the Jung dataset, p=0.0055 for progression-free survival.