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. 2021 Sep 15;11:699847. doi: 10.3389/fonc.2021.699847

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Copyright © 2021 Dai, Tang, Ruan, Bajinka, Liu and Tan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gimap5 altered the distribution of M6PR on the lung cancer cells surface. (A) The co-location of Gimap5 and M6PR were examined in PC9-Gimap5 cells and Beas-2b-Gimap5 cells. (magnification, × 1000). (B) Molecular docking diagram of Gimap5 and M6PR. (C) The effect of Gimap5 overexpression on the transcription level of M6PR (ns means no significance). (D) The effect of Gimap5 overexpression on the protein level of M6PR. After the image scanning gray analysis, the internal reference GAPDH correction was used to obtain the ratio of each group (ns means no significance; **p < 0.01 vs. empty vector). (E) Pattern diagram of action mechanism of GIMAP5 GTPase. (F) Gimap5 altered the intracellular distribution of M6PR (magnification, × 400).