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. 2021 Sep 15;12:734304. doi: 10.3389/fimmu.2021.734304

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Copyright © 2021 Phelps and Balazs

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Fc-mediated effector functions. Antibodies can engaged with phagocytes, such as monocytes macrophages and neutrophyls through FcγRIa and FcγRIIa to drive antibody-dependent cellular phagocytosis.Nk cells can engaged with antibodies through engagement with FcγRIIIa to drive antibody-dependent cellular cytotoxicity. Antibodies can also activate the classical complement pathway to derive complement dependent cytotoxicity.