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. 2021 Sep 15;11:714267. doi: 10.3389/fonc.2021.714267

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Copyright © 2021 Zhu, Jia, Wang, Song, Wang, Yang and Shi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Genetic landscape and expression changes of the m6A regulator in bladder cancer. (A) Mutation frequency of the m6A regulators of bladder cancer patients in the TCGA-BLCA cohort. (B) A histogram plotting the mutation frequency of each gene obtained by statistical analysis of the copy number of m6A. The abscissa was the m6A-related gene, and the ordinate was the mutation frequency. Red represents an increase in copy number, and green represents loss of copy number. (C) The m6A copy number circle graph. Red represents the sample with missing gene copy number than the sample with increasing copy number. Green represents the sample with missing gene copy number than the sample with increasing copy number. (D) The box plot of m6A differential expression analysis. Red represents the tumor sample, and green represents the normal sample. The *** represents p < 0.0001, ** represents p < 0.01, * represents p < 0.05.