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. 2021 Sep 15;11:736955. doi: 10.3389/fonc.2021.736955

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Copyright © 2021 Lou, Wei, Yang, Wang, Yang, Zheng, Zhu and Yan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PD-1 receptor occupancy and pharmacokinetic profiles of GLS-010 in cynomolgus macaques. (A) PD-1 receptor occupancy rate of activated CD3⁺ T cells of different doses of GLS-010 in cynomolgus macaques on day 50 and day 206. (B) Pharmacokinetic profiles of different doses of GLS-010 divided by sex in cynomolgus macaques.