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Binding affinity of GLS-010 to hPD-1 protein by SPR.
| Analyte | Ligand | ka (1/Ms) | kd (1/s) | KD (M) | Rmax (RU) | Chi2 (RU) |
|---|---|---|---|---|---|---|
| Human PD-1.ECD.His | GLS-010 | 1.12E+06 | 1.96E-04 | 1.75E-10 | 54.14 | 2.58 |
| Nivolumab | 7.76E+05 | 8.97E-04 | 1.16E-09 | 68.9 | 2.2 |
SPR, surface plasmon resonance; ka, association rate constant; kd, dissociation rate constant; KD, affinity constant; Rmax, maximum observed response; Chi2, goodness of fit indicator.
