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. 2021 Sep 15;11:703461. doi: 10.3389/fonc.2021.703461

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Copyright © 2021 Wang, Dong, Wu, Wang, Shi and Zheng

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cancer-specific circRNAs and host genes, and top actively back-spliced host genes. (A) Venn diagram showing the overlap between the host genes of circRNAs in pan-cancer and pan-normal tissues. (B) Venn diagram showing the overlap between circRNA profiles of pan-cancer and pan-normal tissues. (C) Cancer-specific circRNAs harbored by different counts of samples. (D) Functional enrichment of the host genes of the stably expressed cancer-specific circRNAs. (E) Top 30 actively back-spliced host genes in pan-cancer tissues. Proportion of total circRNA types related to the same host gene represents the back-splicing activity. (F) Top 30 actively back-spliced host genes in pan-normal tissues. (G) Functional enrichment of the top 30 actively back-spliced host genes in the pan-cancer and pan-normal tissues. (H) Overlap between the top actively back-spliced host genes in pan-cancer and pan-normal tissues.