Figure 4.

Pan-cancer tissue-enriched circRNAs. (A) Heatmap illustrating the expression of pan-cancer tissue-enriched circRNAs identified by co-expression analysis. Firebrick, orange-red, salmon, white-smoke, sienna, dark-olive-green, coral, and deep-pink represent co-expression modules. Red: pan-cancer tissues; blue: pan-normal tissues; rainbow: tissue types. (B) Receiver operating characteristic curve showing the sensitivity of pan-cancer tissue-enriched circRNAs to classify pan-cancer and pan-normal tissues via the support vector machine. Different circRNA co-expression modules were analyzed. Blue: training set; red: validation set. (C) Receiver operating characteristic curve showing the sensitivity of pan-cancer tissue-enriched circRNAs to classify pan-cancer and pan-normal tissues via the support vector machine. These pan-cancer tissue-enriched circRNAs were selected from the firebrick, orange-red, and salmon co-expression modules. Blue: training set; red: validation set. (D) Functional enrichment of the host genes of pan-cancer tissue-enriched circRNAs among the top 10% stably expressed circRNAs, which are the firebrick, orange-red, and salmon co-expression modules.