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. 2021 Sep 15;11:703461. doi: 10.3389/fonc.2021.703461

Figure 5.

Figure 5

Expression of pan-cancer tissue-enriched and pan-normal tissue-enriched circRNAs in plasma exosomes based on exoRbase data. (A) Principle component analysis of plasma exosomal circRNA profiles of healthy controls (HC), hepatocellular carcinoma patients (HCC), colorectal cancer patients (CRC), and pancreatic adenocarcinoma patients (PAAD). (B) Abundance of circRNAs in plasma exosomes from HC, HCC, CRC, and PAAD. (C) Sparsity of circRNA profiles in plasma exosomes from HC, HCC, CRC, and PAAD. (D) Abundance of cancer tissue-specific circRNAs, pan-cancer tissue-enriched circRNAs, and pan-normal tissue-enriched circRNAs in HC, HCC, CRC, and PAAD. (E) Expression of chr1:224952669:G>A (DNAH14)-related circRNAs in plasma exosomes from HC, HCC, CRC, and PAAD. (F) Expression of other cancer mutation-related pan-cancer tissue-enriched circRNAs in plasma exosomes from HC, HCC, CRC, and PAAD. (G) Expression of pan-normal tissue-enriched circRNAs in plasma exosomes from HC, HCC, CRC, and PAAD.